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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/24114
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Title: | Dual-lumen power injectable peripherally inserted central catheters in allogeneic hematopoietic stem cell transplantation: A prospective observational study |
Authors: | Shih, YH;Teng, CLJ;Chen, TC;Chang, KH;Chen, MH |
Keywords: | allo-HSCT;cyclosporine;polyurethane;power injectable PICCs |
Date: | 2021 |
Issue Date: | 2022-08-05T09:48:03Z (UTC)
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Publisher: | WILEY |
ISSN: | 0962-1067 |
Abstract: | Aims and Objectives To explore whether dual-lumen power injectable peripherally inserted central catheters (PICCs) could be effectively and safely applied in allogeneic hematopoietic stem cell transplantation (allo-HSCT) and for serum cyclosporine level monitoring. Background Compared to conventional central venous access devices, PICC provides a feasible route not only for fluid infusion, but also for blood sample collection in patients undergoing oncological treatments. Design A prospective observational study was conducted according to the STROBE guidelines. Methods We prospectively evaluated the applications and complications of power injectable PICCs in 52 consecutive allo-HSCT recipients. We also compared the cyclosporine levels in 188 paired blood samples, simultaneously obtained via power injectable PICCs and percutaneous venous puncture, to investigate whether power injectable PICC is a feasible route for cyclosporine concentration monitoring in allo-HSCT. Results The median PICC placement duration was 29 days. The insertion-site blood oozing and central line-associated bloodstream infection rates were 36.5% (19/52) and 26.9% (14/52), respectively, indicating the feasibility of these PICCs for various applications in allo-HSCT. No power injectable PICC-related thrombotic adverse events were identified; 90.4% (47/52) of cases with power injectable PICC removal occurred because of lack of medical utility, suggesting that power injectable PICC-related complications were manageable. However, cyclosporine levels in samples obtained via these PICCs were significantly higher than those in samples obtained via percutaneous venous puncture (261.5 +/- 139.2 vs. 232.4 +/- 253.6 ng/ml; p = 0.019 [set 1]; 254.8 +/- 89.3 vs. 225.1 +/- 233.3 ng/ml; pp = 0.006 [set 3]; 291.0 +/- 94.9 vs. 266.0 +/- 274.7 ng/ml; p = 0.016 [set 4]). Conclusion The power injectable PICC is a feasible venous access device for allo-HSCT. Relevance to clinical practice The dual-lumen power injectable PICCs provided a reliable access for blood sample collection, decreasing the number of blind percutaneous venous punctures in allo-HSCT. However, its application in cyclosporine level monitoring needs further investigation. |
URI: | http://dx.doi.org/10.1111/jocn.16020 https://www.webofscience.com/wos/woscc/full-record/WOS:000690792500001 https://ir.csmu.edu.tw:8080/handle/310902500/24114 |
Relation: | JOURNAL OF CLINICAL NURSING ,2022,v31,issue 11-12, P1654-1661 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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