中山醫學大學機構典藏 CSMUIR:Item 310902500/24088
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    題名: Association of Metabolic Syndrome with Aerobic Exercise and LPL rs3779788 Polymorphism in Taiwan Biobank Individuals
    作者: Hsu, CS;Chang, ST;Nfor, ON;Lee, KJ;Ho, CC;Liu, CC;Lee, SS;Liaw, YP
    關鍵詞: polymorphisms;variant;physical activity;metabolic disorders
    日期: 2021
    上傳時間: 2022-08-05T09:47:37Z (UTC)
    出版者: DOVE MEDICAL PRESS LTD
    ISSN: 1178-7007
    摘要: Purpose: The Lipoprotein lipase (LPL) gene is a significant contributor to dyslipidemia. It has shown associations with several conditions including atherosclerosis, obesity, and metabolic syndrome (MetS). We assessed the interactive association between MetS and rs3779788 of the LPL gene based on aerobic exercise. Materials and Methods: Data were available for 7532 Taiwan Biobank (TWB) participants recruited between 2008 and 2016. We used multiple logistic regression to determine the odds ratios (OR) for MetS and their 95% confident intervals (C.I.). Potential variables included LPL rs3779788, aerobic exercise, sex, age, education, marital status, body mass index (BMI), smoking, alcohol consumption, midnight snacking, vegetarian diet, coffee, dietary fat, and tea drinking. Results: Aerobic exercise was protective against MetS (OR, 0.858; 95% C.I., 0.743-0.991). Compared to CC/CT genotype, the OR for developing MetS was 0.875, (95% C.I., 0.571- 1.341) in TT individuals. The test for interaction was significant for the rs3779788 variant and aerobic exercise (p = 0.0484). In our group analyses, the OR for MetS was 0.841 (95% C.I., 0.727-0.974) in CC/CT and 4.076 (95% C.I., 1.158-14.346) in TT individuals who did aerobic exercise compared to those who did not. Conclusion: Our study indicated that aerobic exercise improved metabolic syndrome in Taiwanese adults with rs3779788 CC/CT genotype relative to those with TT genotype.
    URI: http://dx.doi.org/10.2147/DMSO.S328308
    https://www.webofscience.com/wos/woscc/full-record/WOS:000697029700004
    https://ir.csmu.edu.tw:8080/handle/310902500/24088
    關聯: DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY ,2021,v14 , P3997-4004
    顯示於類別:[中山醫學大學研究成果] 期刊論文

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