Association between Traditional Chinese medicine and a lower risk of dementia in patients with major depression: A case-control study

doi:10.1016/j.jep.2021.114291

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24075

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24075

Title:	Association between Traditional Chinese medicine and a lower risk of dementia in patients with major depression: A case-control study
Authors:	Lin, SK;Wang, PH;Huang, CH;Kuo, YH;Lai, JN;Wei, JCC
Keywords:	Dementia;Major depression;Traditional Chinese medicine;Dispersing qi;Dementia risk;Blood circulation activation;Bupleurum Chinese
Date:	2021
Issue Date:	2022-08-05T09:47:26Z (UTC)
Publisher:	ELSEVIER IRELAND LTD
ISSN:	0378-8741
Abstract:	Ethnopharmacological relevance: Major depression is an important risk factor for dementia. Traditional Chinese medicine (TCM) can alleviate the symptoms of major depression. However, it is unclear whether TCM decreases the risk of dementia in patients with major depression. Therefore, in this nationwide case-control study, we aimed to evaluate the association between TCM and the risk of dementia. Materials and methods: We included 31,981 major depression patients with dementia from the National Dementia Database as the case group, and 4391 major depression patients without dementia from a one-million random sample database as the control group. We matched age (plus or minus two years), sex, and year of depression diagnosis based on a 1:4 ratio. Result: There were 11,724 and 2931 patients in the case and control groups, respectively. Based on a conditional logistic regression analysis, the TCM groups exhibited significantly lower odds ratios with a 95% confidence interval of 0.83 (0.74-0.91). TCM treatment for more than 90 days, dispersing Qi, and activating blood circulation resulted in lower dementia risk with the following odds ratios and 95% confidence intervals: 0.60 (0.56-0.68), 0.87 (0.74-1.08), and 0.66 (0.49-0.81). Conclusion: The results suggest that TCM is associated with lower dementia risk in major depression patients.
URI:	http://dx.doi.org/10.1016/j.jep.2021.114291 https://www.webofscience.com/wos/woscc/full-record/WOS:000696990200005 https://ir.csmu.edu.tw:8080/handle/310902500/24075
Relation:	JOURNAL OF ETHNOPHARMACOLOGY ,2021,v278
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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