Higher Risk for Sjogren's Syndrome in Patients With Fibromyalgia: A Nationwide Population-Based Cohort Study

doi:10.3389/fimmu.2021.640618

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24071

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24071

Title:	Higher Risk for Sjogren's Syndrome in Patients With Fibromyalgia: A Nationwide Population-Based Cohort Study
Authors:	Gau, SY;Leong, PY;Lin, CL;Tsou, HK;Wei, JCC
Keywords:	fibromyalgia;cohort;Sjö gren’ s syndrome;population based study;NHIRD
Date:	2021
Issue Date:	2022-08-05T09:47:22Z (UTC)
Publisher:	FRONTIERS MEDIA SA
ISSN:	1664-3224
Abstract:	Objectives Clinically, associations have been observed between Sjogren's syndrome and fibromyalgia. Nonetheless, population-based evidence evaluating the risk of Sjogren's syndrome in fibromyalgia patients is lacking. The main purpose of this retrospective cohort study was to determine the association between fibromyalgia and subsequent development of Sjogren's syndrome. Methods This retrospective cohort study extracted data from the Longitudinal Health Insurance Database (LHID) of the Taiwan National Health Insurance (NHI). During 2000-2012, patients with newly-diagnosed fibromyalgia (International Classification of Diseases, Ninth Revision, Clinical Modification code 729.1) were defined as the exposure cohort. Age- and gender-matched individuals without fibromyalgia were used as the comparison cohort. The adjusted hazard ratios (aHR) for the occurrence of Sjogren's syndrome in those with fibromyalgia were evaluated along with stratified analyses of different subgroups. Results Of the 149,706 subjects whose data were extracted from the LHID, 74,853 subjects had coded fibromyalgia and 74,853 control subjects were without fibromyalgia. Compared to the control group, patients with fibromyalgia had an aHR of 2.00 (95% Confidence Interval [CI], 1.52-2.61) for developing Sjogren's syndrome. In fibromyalgia patients aged 20-49 years, the aHR for future Sjogren's syndrome was 3.07 (95% CI, 1.92-4.89). Conclusion Patients with fibromyalgia, both males and females, have a higher risk for developing Sjogren's syndrome than those without fibromyalgia, especially those aged 20-49 years. While managing patients, clinicians should be aware of the bidirectional association between the two diseases, which helps to understand the impact of the association on disease activity and diagnosis.
URI:	http://dx.doi.org/10.3389/fimmu.2021.640618 https://www.webofscience.com/wos/woscc/full-record/WOS:000643720300001 https://ir.csmu.edu.tw:8080/handle/310902500/24071
Relation:	FRONTIERS IN IMMUNOLOGY ,2021,v12
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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