Endometriosis and New-Onset Coronary Artery Disease in Taiwan: A Nationwide Population-Based Study

doi:10.3389/fmed.2021.619664

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24061

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24061

Title:	Endometriosis and New-Onset Coronary Artery Disease in Taiwan: A Nationwide Population-Based Study
Authors:	Wei, CH;Chang, R;Wan, YH;Hung, YM;Wei, JCC
Keywords:	coronary artery disease;endometriosis;cohort study;CAD;new-onset
Date:	2021
Issue Date:	2022-08-05T09:47:13Z (UTC)
Publisher:	FRONTIERS MEDIA SA
Abstract:	Endometriosis (EM) with chronic inflammation may accelerate the progression of atherosclerosis. Currently, no large or randomized clinical studies have assessed the incidence of cardiovascular events in patients with endometriosis in Asia to investigate whether incident EM is associated with a higher risk of new-onset coronary artery disease (CAD). In this study of a nationwide cohort in Taiwan, we identified 13,988 patients with newly diagnosed EM from 1 January, 2000, through 31 December, 2012. EM and non-EM groups were matched by propensity score at a ratio of 1:1. Of a total 27,976 participants, 358 developed CAD. The incidence rate in the EM group was higher than that in the non-EM group (1.8 per 1,000 person-years vs. 1.3 per 1,000 person-years) during the follow-up period. The adjusted hazard ratio (aHR) of CAD for the EM group was 1.52 with a 95% confidence interval (1.23-1.87, p < 0.001) after adjusting for demographic characteristics, comorbidities, surgical procedures, frequency of outpatient visits, and medications. Stratified analysis revealed that, among four age groups (20-39, 40-49, 50-54, and above 55 years), the 20-39 years sub-group was associated with a higher risk of CAD (aHR, 1.73; 95% CI, 1.16-2.59, p = 0.008). Several sensitivity analyses were conducted for cross-validation, and it showed consistent positive findings. In conclusion, this cohort study revealed that patients with symptomatic EM in Taiwan were associated with increased risk of subsequent CAD than patients without medical records of EM. Further prospective studies are needed to confirm this causal relationship.
URI:	http://dx.doi.org/10.3389/fmed.2021.619664 https://www.webofscience.com/wos/woscc/full-record/WOS:000674735300001 https://ir.csmu.edu.tw:8080/handle/310902500/24061
Relation:	FRONTIERS IN MEDICINE ,2021,v8
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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