Features of indeterminate results of QuantiFERON-TB Gold In-Tube test in patients with haematological malignancies

doi:10.1177/20406207211028437

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24053

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24053

Title:	Features of indeterminate results of QuantiFERON-TB Gold In-Tube test in patients with haematological malignancies
Authors:	Huang, CC;Teng, CLJ;Wu, MF;Lee, CH;Chen, HC;Huang, WC
Keywords:	haematological malignancy;indeterminate;QuantiFERON-TB Gold in-Tube
Date:	2021
Issue Date:	2022-08-05T09:47:04Z (UTC)
Publisher:	SAGE PUBLICATIONS LTD
ISSN:	2040-6207
Abstract:	Background and aims: The application of QuantiFERON-TB Gold in-Tube (QFT-GIT) in patients with haematological malignancies (HMs) has not been well studied. Therefore, we aimed to investigate the features of patients with HMs whose QFT-GIT results were indeterminate. Methods: This study enrolled patients with HMs for the analysis of QFT-GIT tests and additional 2-year follow-up. The characteristics and predictors of QFT-GIT indeterminate results were identified. Mycobacterium tuberculosis (TB) incidence rate (IR) and incidence rate ratio (IRR) were also investigated. Results: Of 89 participants, 27 (30.3%) had QFT-GIT indeterminate results. The QFT-GIT indeterminate patients were characterized with the diagnosis of leukaemia (63.0% versus 32.3%, p=0.044), abnormal white blood count (WBC) (88.9% versus 14.5%, p=0.001), abnormal lymphocyte percentage (81.5% versus 14.5%, p=0.001) and lower lymphocyte count (x10(9)/l) (0.5 versus 2.2, p=0.000) when compared with those with determinate results. Meanwhile, abnormal WBC [odds ratios (OR): 15.18, p=0.003] and lymphocyte percentage (OR: 6.90, p=0.033) were predictors of indeterminate results. One patient with the QFT-GIT indeterminate status and high interferon-gamma level of negative control result developed active TB with a TB IR of 18.5 per 1000 person-years and an IRR of 0.1 (95% confidence interval, 0.01-0.71) when compared with positive QFT-GIT patients without prophylaxis treatment. Conclusion: Abnormal ranges of WBC and lymphocyte differential count percentage were independent predictors useful to determine the optimal timing of implementing QFT-GIT test in patients with HMs.
URI:	http://dx.doi.org/10.1177/20406207211028437 https://www.webofscience.com/wos/woscc/full-record/WOS:000688008600001 https://ir.csmu.edu.tw:8080/handle/310902500/24053
Relation:	THERAPEUTIC ADVANCES IN HEMATOLOGY ,2021,v12
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	206	View/Open

Loading...