Pyogenic Liver Abscess Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide, Population-Based Cohort Study

doi:10.3389/fmed.2021.675345

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24050

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24050

Title:	Pyogenic Liver Abscess Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide, Population-Based Cohort Study
Authors:	Wang, TY;Lai, HC;Chen, HH;Wang, ML;Hsieh, MC;Chang, CT;Chen, RH;Ho, CW;Hung, YC;Tseng, JY;Lin, CL;Kao, CH
Keywords:	pyogenic liver abscess;newly diagnosed type 2 diabetic mellitus;Klebsiella pneumonia;acarbose;National Health Insurance Research Database
Date:	2021
Issue Date:	2022-08-05T09:47:01Z (UTC)
Publisher:	FRONTIERS MEDIA SA
Abstract:	Background: To date, no comprehensive epidemiological study exists on pyogenic liver abscess (PLA) risk in patients with newly diagnosed type 2 diabetes mellitus (T2DM) worldwide. Methods: We conducted a retrospective cohort study by using data from Taiwan National Health Insurance Research Database (NHIRD) to examine the association between newly diagnosed T2DM and PLA. The T2DM cohort included patients newly diagnosed as having T2DM (ICD-9-CM:250) from 2000 to 2009, with follow-up until December 31, 2011. The comparison cohort was then recruited through 1:4 random frequency matching with the T2DM cohort. Finally, the adjusted hazard ratios for PLA were compared between the T2DM and comparison cohorts, which included 44,728 patients with T2DM and 178,912 patients without DM respectively. Results: In T2DM cohort, 166 patients were diagnosed as having PLA (incidence rate = 5.87 per 10,000 person-years) and in comparison cohort, 238 patients were diagnosed as having PLA (incidence rate = 2.06 per 10,000 person-years). The T2DM cohort exhibited higher PLA risk than did the comparison cohort (hazard ratio = 2.83, 95% confidence interval = 2.32-3.46). Furthermore, the adjusted hazard ratio for PLA risk in T2DM cohort was the highest in those who were younger, man and with duration of DM <2 years. In the T2DM cohort, the most common PLA causative agent was Klebsiella pneumonia (KP). In addition, PLA risk was high in T2DM patients with gallstone and cholecystitis. Compared with comparison cohort, patients with T2DM prescribed acarbose has a lower PLA risk, however glyburide significantly increased PLA risk in T2DM cohort. Conclusion: In patients with newly diagnosed T2DM, PLA risk was high and acarbose might reduce PLA risk.
URI:	http://dx.doi.org/10.3389/fmed.2021.675345 https://www.webofscience.com/wos/woscc/full-record/WOS:000654214800001 https://ir.csmu.edu.tw:8080/handle/310902500/24050
Relation:	FRONTIERS IN MEDICINE ,2021,v8
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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