1-Nitropyrene Induced Reactive Oxygen Species-Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation

doi:10.1155/2021/9314342

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24028

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題名:	1-Nitropyrene Induced Reactive Oxygen Species-Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation
作者:	Su, CH;Ho, YC;Lee, MW;Tseng, CC;Lee, SS;Hsieh, MK;Chen, HH;Lee, CY;Wu, SW;Kuan, YH
日期:	2021
上傳時間:	2022-08-05T09:46:42Z (UTC)
出版者:	HINDAWI LTD
ISSN:	1942-0900
摘要:	1-Nitropyrene (1-NP), one of the most abundant nitropolycyclic aromatic hydrocarbons (nitro-PAHs), is generated from the incomplete combustion of carbonaceous organic compounds. 1-NP is a specific marker of diesel exhaust and is an environmental pollutant and a probable carcinogen. Macrophages participate in immune defense against the invasive pathogens in heart, lung, and kidney infection diseases. However, no evidence has indicated that 1-NP induces apoptosis in macrophages. In the present study, 1-NP was found to induce concentration-dependent changes in various cellular functions of RAW264.7 macrophages including cell viability reduction; apoptosis generation; mitochondrial dysfunction; apoptosis-inducing factor (AIF) nuclear translocation; intracellular ROS generation; activation of the AMPK/Nrf-2/HO-1 pathway; changes in the expression of BCL-2 family proteins; and depletion of antioxidative enzymes (AOE), such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) These results indicate that 1-NP induced apoptosis in macrophages through AIF nuclear translocation and ROS generation due to mitochondrial dysfunction and to the depletion of AOE from the activation of the AMPK/Nrf-2/HO-1 pathway.
URI:	http://dx.doi.org/10.1155/2021/9314342 https://www.webofscience.com/wos/woscc/full-record/WOS:000680527100003 https://ir.csmu.edu.tw:8080/handle/310902500/24028
關聯:	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY ,2021,v2021
顯示於類別:	[中山醫學大學研究成果] 期刊論文

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