Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study

doi:10.1155/2021/1298487

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24019

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24019

Title:	Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study
Authors:	Chen, HH;Wu, CT;Tsai, YT;Ho, CW;Hsieh, MC;Lai, JN
Date:	2021
Issue Date:	2022-08-05T09:46:31Z (UTC)
Publisher:	HINDAWI LTD
ISSN:	1741-427X
Abstract:	Introduction. Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use. Materials and Methods. This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model. Results. In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56-0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82-0.90) and presented a dose-dependent effect. Conclusion. The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes.
URI:	http://dx.doi.org/10.1155/2021/1298487 https://www.webofscience.com/wos/woscc/full-record/WOS:000691122200002 https://ir.csmu.edu.tw:8080/handle/310902500/24019
Relation:	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE ,2021,v2021
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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