Electrosprayed calcium silicate nanoparticle-coated titanium implant with improved antibacterial activity and osteogenesis

doi:10.1016/j.colsurfb.2021.111699

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24011

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题名:	Electrosprayed calcium silicate nanoparticle-coated titanium implant with improved antibacterial activity and osteogenesis
作者:	Buga, C;Chen, CC;Hunyadi, M;Csik, A;Hegedus, C;Ding, SJ
关键词:	Calcium silicate;Electrospray deposition;Bonding strength;Bioactive coating;Antibacterial coating
日期:	2021
上传时间:	2022-08-05T09:46:24Z (UTC)
出版者:	ELSEVIER
ISSN:	0927-7765
摘要:	To ensure clinical success, the implant and the surrounding bone tissue must not only be integrated, but also must not be suspected of infection. In this work, an antibacterial and bioactive nanostructured calcium silicate (CaSi) layer on titanium substrate by an electrospray deposition method was prepared, followed by annealing at 700, 750 and 800 degrees C to improve the bonding strength of the CaSi coating. The phase composition, microstructure and bonding strength of the CaSi coatings were examined. Human mesenchymal stem cells (hMSCs), Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) species were used to analyze the osteogenic and antibacterial activity of the coatings, respectively. Experimental results showed that the as-prepared CaSi coating was mainly composted of beta-dicalcium silicate phase with a particle size of about 300 nm. After annealing, the thickness of the oxidation reaction layer increased obviously from 0.3 mu m to 1 mu m with increase in temperature, which was confirmed by the cross-sectional morphology and element depth profile. The bonding strength of the coating annealed at 750 degrees C (19.0 MPa) was significantly higher (p < 0.05) than that of the as-prepared coating (4.4 MPa) and the ISO 13,779 standard (15 MPa). The results of antibacterial efficacy and stem cell osteogenesis consistently elaborated that the 750 degrees C-annealed coating had higher activity than the as-prepared coating and the Ti control. It is concluded that after annealing at 750 degrees C, the CaSi nanoparticlecoated Ti implant had good bond strength, osteogenic and antibacterial activity.
URI:	http://dx.doi.org/10.1016/j.colsurfb.2021.111699 https://www.webofscience.com/wos/woscc/full-record/WOS:000663336700006 https://ir.csmu.edu.tw:8080/handle/310902500/24011
關聯:	COLLOIDS AND SURFACES B-BIOINTERFACES ,2021,v202
显示于类别:	[中山醫學大學研究成果] 期刊論文

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