中山醫學大學機構典藏 CSMUIR:Item 310902500/23999
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    题名: Influenza Vaccination Is Associated With Lower Incidental Asthma Risk in Patients With Atopic Dermatitis: A Nationwide Cohort Study
    作者: Li, KH;Leong, PY;Tseng, CF;Wang, YH;Wei, JCC
    关键词: asthma;atopic dermatitis;big data analysis;influenza vaccination;Taiwan national health insurance research database
    日期: 2021
    上传时间: 2022-08-05T09:46:14Z (UTC)
    出版者: FRONTIERS MEDIA SA
    ISSN: 1664-3224
    摘要: Background Atopic march refers to the natural history of atopic dermatitis (AD) in infancy followed by subsequent allergic rhinitis and asthma in later life. Respiratory viruses interact with allergic sensitization to promote recurrent wheezing and the development of asthma. We aimed to evaluate whether influenza vaccination reduces asthma risk in people with AD. Methods This cohort study was conducted retrospectively from 2000 to 2013 by the National Health Insurance Research Database (NHIRD). Patients with newly diagnosed AD (International Classification of Diseases, Ninth Revision, Clinical Modification code 691) were enrolled as the AD cohort. We matched each vaccinated patient with one non-vaccinated patient according to age and sex. We observed each participant until their first asthma event, or the end of the study on December 31, 2013, whichever came first. Results Our analyses included 4,414 people with a mean age of 53 years. Of these, 43.8 were male. The incidence density of asthma was 12.6 per 1,000 person-years for vaccinated patients, and 15.1 per 1000 person-years for non-vaccinated patients. The adjusted hazard ratio (aHR) of asthma in the vaccinated cohort relative to the non-vaccinated cohort was 0.69 (95% CI = 0.55-0.87). Vaccinated patients had a lower cumulative incidence of asthma than unvaccinated patients. Vaccinated participants in all age and sex groups trended toward a lower risk of asthma. People will reduce more asthma risk when taking shots every year. Conclusion Influenza vaccination was associated with lower asthma risk in patients with AD.
    URI: http://dx.doi.org/10.3389/fimmu.2021.729501
    https://www.webofscience.com/wos/woscc/full-record/WOS:000713228300001
    https://ir.csmu.edu.tw:8080/handle/310902500/23999
    關聯: FRONTIERS IN IMMUNOLOGY ,2021,v12
    显示于类别:[中山醫學大學研究成果] 期刊論文

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