中山醫學大學機構典藏 CSMUIR:Item 310902500/23990
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    题名: Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study
    作者: Chen, ZY;Xu, YW;Chen, M;Cui, R;Wang, YH;Dai, SM;Wei, JCC
    关键词: gout;psoriasis;cardiovascular disease;epidemiology;population based cohort study
    日期: 2021
    上传时间: 2022-08-05T09:46:05Z (UTC)
    出版者: FRONTIERS MEDIA SA
    ISSN: 1664-3224
    摘要: Objective Patients with psoriasis (PsO) have a high frequency of concomitant gout and increased risk of cardiovascular diseases (CVD). We aimed to estimate the synergistic impact of gout on the risk of CVD in patients with PsO. Methods A population-based cohort of patients registered in the National Health Insurance Research Database of Taiwan between 2000 and 2013 was stratified according to the presence of PsO and gout. Propensity score analysis was used to match age and gender at a ratio of 1:4. Cox proportional hazard models and subgroup analyses were used to estimate the hazard ratios (HRs) for CVD adjusted for traditional risk factors. The Kaplan-Meier method was used to plot the cumulative incidence curves. Results Patients with combined PsO and gout (n = 97), PsO alone (n = 388), gout alone (matched, n = 388) and matched controls (n = 388) were identified. Compared with the patients with PsO alone, the patients with combined PsO and gout had a significantly higher risk of CVD (relative risk 2.39, 95% CI 1.56 to 3.65). After adjustment for traditional risk factors, the risk of CVD was higher in patients with gout alone (HR 2.16, 95% CI 1.54 to 3.04) and in patients with combined PsO and gout (HR 2.72, 95% CI 1.73 to 4.28). Conclusions Gout augments the risk of CVD independently of traditional risk factors in patients with PsO.
    URI: http://dx.doi.org/10.3389/fimmu.2021.703119
    https://www.webofscience.com/wos/woscc/full-record/WOS:000679266400001
    https://ir.csmu.edu.tw:8080/handle/310902500/23990
    關聯: FRONTIERS IN IMMUNOLOGY ,2021,v12
    显示于类别:[中山醫學大學研究成果] 期刊論文

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