Direct-acting antiviral treatment for Hepatitis C Virus in geriatric patients: a real-world retrospective comparison between early and late elderly patients

doi:10.7717/peerj.10944

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23957

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23957

Title:	Direct-acting antiviral treatment for Hepatitis C Virus in geriatric patients: a real-world retrospective comparison between early and late elderly patients
Authors:	Yen, HH;Su, PY;Liu, IL;Zeng, YY;Huang, SP;Hsu, YC;Yang, CW;Chen, YY
Keywords:	Hepatitis C;Geriatric;Viral hepatitis;Direct-acting antiviral treatment
Date:	2021
Issue Date:	2022-08-05T09:45:34Z (UTC)
Publisher:	PEERJ INC
ISSN:	2167-8359
Abstract:	Introduction. Chronic hepatitis C virus (HCV) infection rates are high in the geriatric population considering that interferon-based therapy is usually intolerable. With the introduction of oral antiviral therapy for HCV, increased treatment tolerability and good treatment responses have been observed. However, treatment data regarding the geriatric population have been limited. Therefore, this retrospective study aimed to evaluate the efficacy and safety of direct-acting antiviral therapy for HCV in the geriatric population. Materials and Methods. The primary end point was sustained virologic response (SVR) 12 weeks after treatment completion, whereas the secondary end points were treatment-related side effects and short-term survival rate following treatment. Results. In total, 492 patients (median age, 73 years; 43.9% males), including 278 early elderly patients, were enrolled. Among the included patients, 45% had cirrhosis. HCV genotypes 1 (72.4%) and 2 (25.4%) were the most common. The overall SVR rate was 96.7%, with no difference in SVR rates observed between early and late elderly groups (96.8% vs. 96.7%; p = 0 :983). Both groups showed similar side effects, including dizziness (11.4%), and fatigue (8.7%), with three patients discontinuing therapy owing to side effects. Both groups had a similar 3-year survival rate. Significant factors associated with post-treatment survival included cirrhosis, albumin, and creatinine level. Conclusions. Our real-world data showed that both early and late elderly patients could undergo direct-acting antiviral treatment for HCV with excellent treatment outcomes.
URI:	http://dx.doi.org/10.7717/peerj.10944 https://www.webofscience.com/wos/woscc/full-record/WOS:000629622900003 https://ir.csmu.edu.tw:8080/handle/310902500/23957
Relation:	PEERJ ,2021,v9
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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