Objective: This study aimed to investigate the association of age and sex with metabolic syndrome (MS) in Taiwanese adults. Methods: We extracted information of 4307 men and 4783 women aged 30-70 from the Taiwan Biobank. Results: The interaction between age and sex on MS was significant (p-value = 0.0001). After stratification by sex, men and women aged 50-70 years (reference: 30 <= age<50 years) had a higher risk of MS. The odds ratio (OR), 95% confidence interval (CI) was 2.316, 1.936-2.772 in men and 3.101, 2.561-3.754 in women. After stratification by age, men aged 50-70 years had a lower risk of MS compared to women (OR, 95% CI = 0.713, 0.598-0.851). Conclusion: The interaction between age and sex on MS was significant. Sex-wise, both men and women aged 50-70 years had a higher likelihood of MS. Age-wise, men aged 50-70 years had a lower risk of MS compared to women.
