中山醫學大學機構典藏 CSMUIR:Item 310902500/23923
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23923


    题名: Aqueous Mulberry Leaf Extract Ameliorates Alcoholic Liver Injury Associating with Upregulation of Ethanol Metabolism and Suppression of Hepatic Lipogenesis
    作者: Lee, YJ;Tsai, MC;Lin, HT;Wang, CJ;Kao, SH
    日期: 2021
    上传时间: 2022-08-05T09:45:02Z (UTC)
    出版者: HINDAWI LTD
    ISSN: 1741-427X
    摘要: Excessive alcohol intake is a major cause of chronic liver damage and is highly associated with the development of a spectrum of hepatic disorders, including steatohepatitis, liver cirrhosis, and liver cancer. Thus, we aimed to explore the hepatoprotective effects of an aqueous mulberry leaf extract (AME) on alcoholic fatty liver disorder (AFLD) by using a mouse model fed with excessive ethanol. Compared with the normal diet, the ethanol diet significantly increased the body weight of the mice, while the AME supplement reduced the weight gain caused by the ethanol diet. The ethanol diet also attenuated the activity of alcohol dehydrogenase and antioxidant enzymes but increased lipid peroxidation in the liver, which were reversed by AME supplementation. Additionally, AME supplementation diminished the ethanol diet-induced hepatic leukocyte infiltration and expressions of IL-6 and TNF alpha. Moreover, AME supplementation also reduced the ethanol-diet-induced lipid accumulation and expression of 1-acylglycerol-3-phosphate acyltransferase, acetyl-CoA carboxylase, low-density lipoprotein receptor, and sterol regulatory element-binding protein-1/2 in the liver. Collectively, AME supplementation improved liver lipid accumulation and proinflammatory response in mice induced by the ethanol diet, which was associated with the upregulation of ethanol-metabolizing enzymes and the downregulation of lipogenesis components.
    URI: http://dx.doi.org/10.1155/2021/6658422
    https://www.webofscience.com/wos/woscc/full-record/WOS:000665073400004
    https://ir.csmu.edu.tw:8080/handle/310902500/23923
    關聯: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE ,2021,v2021
    显示于类别:[中山醫學大學研究成果] 期刊論文

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