Cyano Derivatives of 7-Aminoquinoline that are Highly Emissive in Water: Potential for Sensing Applications

doi:10.1002/chem.202100413

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23907

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23907

Title:	Cyano Derivatives of 7-Aminoquinoline that are Highly Emissive in Water: Potential for Sensing Applications
Authors:	Chang, KH;Chao, WC;Yang, YH;Wu, CH;Li, ZB;Chen, HC;Chou, YT;Ho, JAA;Li, XC;Peng, YC;Liao, YC;Liu, KM;Chao, CM;Chou, PT
Keywords:	7-aminoquinoline;azides;bioimaging;fluorescent probes;hydrogen sulfide probes
Date:	2021
Issue Date:	2022-08-05T09:44:47Z (UTC)
Publisher:	WILEY-V C H VERLAG GMBH
ISSN:	0947-6539
Abstract:	6-Cyano-7-aminoquinoline (6CN-7AQ) and 3-cyano-7-aminoquinoline (3CN-7AQ) were synthesized and found to exhibit intense emission with quantum yield as high as 63 % and 85 %, respectively, in water. Conversely, their derivatives 6-cyano-7-azidoquinoline (6CN-7N(3)Q) and 3-cyano-7-azidoquinoline (3CN-7N(3)Q) show virtually no emission, which makes them suitable to be used as recognition agents in azide reactions based on fluorescence recovery. Moreover, conjugation of 6CN-7AQ with a hydrophobic biomembrane-penetration peptide PFVYLI renders a nearly non-emissive 6CN-7AQ-PFVYLI composite, which can be digested by proteinase K, recovering the highly emissive 6CN-7AQ with similar to 200-fold enhancement. The result provides an effective early confirmation for RT-qPCR in viral detection.
URI:	http://dx.doi.org/10.1002/chem.202100413 https://www.webofscience.com/wos/woscc/full-record/WOS:000644428400001 https://ir.csmu.edu.tw:8080/handle/310902500/23907
Relation:	CHEMISTRY-A EUROPEAN JOURNAL ,2021,v27,issue 30, P8040-8047
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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