中山醫學大學機構典藏 CSMUIR:Item 310902500/23877
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23877


    题名: A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications
    作者: Hsieh, YJ;Cheng, HW;Chen, HY;Lee, MW
    关键词: cascade antitumor drug delivery;gellan gum polysaccharide;graphene nanoparticles;transcatheter arterial chemoembolization
    日期: 2021
    上传时间: 2022-08-05T09:44:19Z (UTC)
    出版者: MDPI
    摘要: The purpose of this study was to develop a four-step cascade drug-release system for transcatheter arterial chemoembolization (TACE) therapeutic applications according to disease-driven and patient-focused design theories. The four steps underlying these strategies involve the blockage of nutrient supply, nanoparticles, codelivery and the cell cytotoxic effect. Calibrated spherical gellan gum (GG) and nanoparticle-containing gellan gum microspheres were prepared using a water-in-oil emulsification method. Self-assembled nanoparticles featuring amine-functionalized graphene oxide (AFGO) as the doxorubicin (Dox) carrier were prepared. The results confirm that, as a drug carrier, AFGO-Dox nanoparticles can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, AFGO-Dox was introduced into gellan gum (GG) microspheres, thus forming GG/AFGO-Dox microspheres with a mean size of 200-700 mu m. After a drug release experiment lasting 28 days, the amount of doxorubicin released from 674 and 226 mu m GG/AFGO-Dox microspheres was 2.31 and 1.18 mu g/mg, respectively. GG/AFGO-Dox microspheres were applied in a rabbit ear embolization model, where ischemic necrosis was visible on the ear after 12 days. Our aim for the future is to provide better embolization agents for transcatheter arterial chemoembolization (TACE) using this device.
    URI: http://dx.doi.org/10.3390/polym13213701
    https://www.webofscience.com/wos/woscc/full-record/WOS:000726540400001
    https://ir.csmu.edu.tw:8080/handle/310902500/23877
    關聯: POLYMERS ,2021,v13,issue 21
    显示于类别:[中山醫學大學研究成果] 期刊論文

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