中山醫學大學機構典藏 CSMUIR:Item 310902500/23864
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    题名: Oral submucous fibrosis stimulates invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by activating MMP-2 and IGF-IR
    作者: Chen, PN;Lin, CW;Yang, SF;Chang, YC
    关键词: epithelial-mesenchymal transition;insulin-like growth factor-1;invasion;oral cancer;oral submucous fibrosis
    日期: 2021
    上传时间: 2022-08-05T09:44:06Z (UTC)
    出版者: WILEY
    ISSN: 1582-1838
    摘要: Oral submucous fibrosis (OSF) involves a high risk of malignant transformation and has been implicated in oral cancer. Limited studies have been conducted on the role of OSF in relation to the invasive capabilities and epithelial-mesenchymal transition (EMT) in oral cancer. Herein, we investigated the effects of OSF on the microenvironment of human oral cancer cells. The results showed that the conditioned medium (CM) of fibrotic buccal mucosal fibroblasts (fBMFs) strongly induced the invasion of oral cancer cells and increased the activities of matrix metalloproteinase-2. OSF significantly induced the EMT in oral cancer cells and downregulated epithelial markers, such as E-cadherin, but significantly elevated vimentin, fibronectin, N-cadherin, RhoA, Rac-1 and FAK. Insulin-like growth factor-1 (IGF-1) was elevated in OSF. The protein levels of the IGF-1R were upregulated specifically in fBMF CM treatment for oral cancer cells, and the IGFR gene was confirmed by The Cancer Genome Atlas patient transcriptome data. The Kaplan-Meier curve analysis revealed that patients with oral squamous cell carcinoma and high IGFR expression levels had poorer 5-year survival than those with low IGFR expression (p = 0.004). The fBMF-stimulated EMT cell model may recapture some of the molecular changes during EMT progression in clinical patients with oral cancer.
    URI: http://dx.doi.org/10.1111/jcmm.16929
    https://www.webofscience.com/wos/woscc/full-record/WOS:000696102400001
    https://ir.csmu.edu.tw:8080/handle/310902500/23864
    關聯: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE ,2021,v25,issue 20, P9814-9825
    显示于类别:[中山醫學大學研究成果] 期刊論文

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