Telomeres and Cancer

doi:10.3390/life11121405

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23799

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23799

Title:	Telomeres and Cancer
Authors:	Fan, HC;Chang, FW;Tsai, JD;Lin, KM;Chen, CM;Lin, SZ;Liu, CA;Harn, HJ
Keywords:	telomerase;telomerase reverse transcriptase;shelterin;CST;promoter mutations
Date:	2021
Issue Date:	2022-08-05T09:43:04Z (UTC)
Publisher:	MDPI
Abstract:	Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin complex, and the CST complex, synergizing with DNA replication, repair, and the RNA metabolism pathway components. As dysfunctional telomere maintenance and telomerase activation are associated with several human diseases, including cancer, the molecular mechanisms behind telomere length regulation and protection need particular emphasis. Cancer cells exhibit telomerase activation, enabling replicative immortality. Telomerase reverse transcriptase (TERT) activation is involved in cancer development through diverse activities other than mediating telomere elongation. This review describes the telomere functions, the role of functional modulators, the implications in cancer development, and the future therapeutic opportunities.
URI:	http://dx.doi.org/10.3390/life11121405 https://www.webofscience.com/wos/woscc/full-record/WOS:000738143400001 https://ir.csmu.edu.tw:8080/handle/310902500/23799
Relation:	LIFE-BASEL ,2021,v11,issue 12
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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