中山醫學大學機構典藏 CSMUIR:Item 310902500/23793
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    题名: Genome-Wide Association Study of Lithium-Induced Dry Mouth in Bipolar I Disorder
    作者: Wu, LSH;Huang, MC;Chen, CK;Shen, CY;Fann, CSJ;Lin, CY;Lin, CC;Cheng, ATA
    关键词: bipolar I disorder;lithium;adverse drug reaction;dry mouth;genome-wide association study (GWAS)
    日期: 2021
    上传时间: 2022-08-05T09:42:58Z (UTC)
    出版者: MDPI
    摘要: Dry mouth is a rather common unpleasant adverse drug reaction (ADR) to lithium treatment in bipolar disorders that often lead to poor adherence or early dropout. The aim of this study was to identify the genetic variants of dry mouth associated with lithium treatment in patients with bipolar I (BPI) disorder. In total, 1242 BPI patients who had ever received lithium treatment were identified by the Taiwan Bipolar Consortium for this study. The proportions of patients who experienced impaired drug compliance during lithium medication were comparable between those only with dry mouth and those with any other ADR (86% and 93%, respectively). Dry mouth appeared to be the most prevalent (47.3%) ADR induced by lithium treatment. From the study patients, 921 were included in a genome-wide association study (GWAS), and replication was conducted in the remaining 321 patients. The SNP rs10135918, located in the immunoglobulin heavy chain locus (IGH), showed the strongest associations in the GWAS (p = 2.12 x 10(-37)) and replication groups (p = 6.36 x 10(-13)) (dominant model) for dry mouth with a sensitivity of 84.9% in predicting dry mouth induced by lithium. Our results may be translated into clinical recommendation to help identify at-risk individuals for early identification and management of dry mouth, which will improve medication adherence.
    URI: http://dx.doi.org/10.3390/jpm11121265
    https://www.webofscience.com/wos/woscc/full-record/WOS:000743826700001
    https://ir.csmu.edu.tw:8080/handle/310902500/23793
    關聯: JOURNAL OF PERSONALIZED MEDICINE ,2021,v11,issue 12
    显示于类别:[中山醫學大學研究成果] 期刊論文

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