Utility of Acute Physiology and Chronic Health Evaluation (APACHE II) in Predicting Mortality in Patients with Pyogenic Liver Abscess: A Retrospective Study

doi:10.3390/jcm10122644

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23769

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题名:	Utility of Acute Physiology and Chronic Health Evaluation (APACHE II) in Predicting Mortality in Patients with Pyogenic Liver Abscess: A Retrospective Study
作者:	Lee, YT;Wang, CC;Li, CF;Chen, HY;Liao, HH;Lin, CC
关键词:	acute physiology and chronic health evaluation II score;intensive care unit;klebsiella pneumoniae;mortality;pyogenic liver abscess;risk factors;sequential organ failure assessment
日期:	2021
上传时间:	2022-08-05T09:42:34Z (UTC)
出版者:	MDPI
摘要:	Pyogenic liver abscess (PLA) is a major life-threatening disease with varied clinical features. This study aimed to determine predictors of mortality in patients with PLA using criteria determined upon admission. We retrospectively examined the data of 324 hospitalized adults in whom liver abscesses were confirmed using abdominal ultrasound and/or computed tomography. The relationship between various risk factors was assessed using multivariate analysis. A total of 109 (33.6%) patients were admitted to the intensive care unit (ICU). The overall mortality rate was 7.4% and was higher among ICU patients than non-ICU patients (21.1% vs. 0.5%, p < 0.001). PLA patients with an Acute Physiology and Chronic Health Evaluation (APACHE) II score >= 18 had a 19.31-fold increased risk, and those with concomitant infections had a 34.33-fold increased risk of 30-day mortality according to multivariate analysis. The estimated area under the receiver operating characteristic curve for predicting 30-day mortality revealed that APACHE II score >= 18 (sensitivity of 75% and specificity of 84%, p < 0.0001) had better discriminative power than Sequential Organ Failure Assessment (SOFA) >= 6 (sensitivity of 81% and specificity of 66%, p < 0.0001). APACHE II has shown better discrimination ability than SOFA in predicting mortality in PLA patients. To improve outcomes in patients with PLA, future management strategies should focus on high-risk patients.
URI:	http://dx.doi.org/10.3390/jcm10122644 https://www.webofscience.com/wos/woscc/full-record/WOS:000666220400001 https://ir.csmu.edu.tw:8080/handle/310902500/23769
關聯:	JOURNAL OF CLINICAL MEDICINE ,2021,v10,issue 12
显示于类别:	[中山醫學大學研究成果] 期刊論文

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