Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of Listeria monocytogenes: A 9-Year Hospital-Based Study

doi:10.3390/biology10111073

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23760

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23760

Title:	Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of Listeria monocytogenes: A 9-Year Hospital-Based Study
Authors:	Huang, SH;Hsieh, MS;Hu, SY;Huang, SC;Tsai, CA;Hsu, CY;Lin, TC;Lee, YC;Liao, SH
Keywords:	area under the curve (AUC);bacteremia;Listeria monocytogenes (LM);mortality in emergency department sepsis (MEDS) score;national early warning score (NEWS);scoring systems;receiver operating characteristic curve (ROC)
Date:	2021
Issue Date:	2022-08-05T09:42:26Z (UTC)
Publisher:	MDPI
Abstract:	Simple Summary:& nbsp;Listeria monocytogenes (LM) may develop life-threatening invasive infections with a mortality rate of 25-30%. The aim of this study is to investigate the scores of LM bacteremia to predict the clinical outcomes. A total of 38 patients were studied, including 16 males (42.1%) and 22 females (57.9%), with a mean age of 59.9 & PLUSMN; 19.6 years. The hospital stay averaged 23.3 & PLUSMN; 20.9 days with an in-hospital mortality rate of 36.8%. The Mortality in Emergency Department Sepsis (MEDS) Score was 6.6 & PLUSMN; 4.0 for survivors and 12.4 & PLUSMN; 4.4 for non-survivors (P < 0.001). The National Early Warning Score (NEWS) was 3.9 & PLUSMN; 2.8 for survivors and 7.8 & PLUSMN; 3.1 for non-survivors (P = 0.001). The AUC of ROC was 0.829 for MEDS and 0.815 for NEWS in predicting the mortality risk. MEDS (& GE;10) and NEWS (& GE;8) were both good predictors of the clinical outcome in LM bacteremia. Further large-scale studies are required to gain a deeper understanding of this disease and to ensure patient safety.<br>Background: Listeria monocytogenes (LM) is a facultative anaerobe, Gram-positive bacillus which is widely distributed in nature, and can be separated from soil, water, and rotten vegetables. Immunocompetent people are less likely to suffer from LM infection or may only show gastrointestinal symptoms. However, immunocompromised elderly people, pregnant women, and newborns may develop life-threatening invasive infections. The mortality rate of LM infection is as high as 25-30%. The aim of this study is to investigate clinical scores of patients with bacteremia of LM confirmed by one or more blood cultures. We analyzed their demographics and laboratory findings in relation to their clinical outcomes. Materials and Methods: This was a hospital-based retrospective study on patients with bacteremia of LM. Data were collected from the electronic clinical database of Taichung Veterans General Hospital between January 2012 and December 2020. Bacteremia of LM was confirmed by at least one blood culture. Demographics, clinical characteristics, and laboratory data were collected for analysis. A variety of clinical scoring systems were used to predict the clinical outcome. Results: A total of 39 patients had confirmed bacteremia of LM. Among them, 1 neonatal patient was excluded. The remaining 38 patients were studied. They included 16 males (42.1%) and 22 females (57.9%), with a mean age of 59.9 & PLUSMN; 19.6 years. Their hospital stay averaged 23.3 & PLUSMN; 20.9 days. The in-hospital mortality rate was 36.8%. Mortality in Emergency Department Sepsis (MEDS) Score was 6.6 & PLUSMN; 4.0 for survivors and 12.4 & PLUSMN; 4.4 for non-survivors (P < 0.001). The National Early Warning Score (NEWS) was 3.9 & PLUSMN; 2.8 for survivors and 7.8 & PLUSMN; 3.1 for non-survivors (P = 0.001). Regarding the prediction of mortality risk, the AUC of ROC was 0.829 for MEDS and 0.815 for NEWS. Conclusions: MEDS and NEWS were both good predictors of the clinical outcome in LM bacteremic patients. In those with higher scores of MEDS (& GE;10) and NEWS (& GE;8), we recommended an early goal-directed therapy and appropriate antibiotic treatment as early as possible to reduce mortality. Further large-scale studies are required to gain a deeper understanding of this disease and to ensure patient safety.
URI:	http://dx.doi.org/10.3390/biology10111073 https://www.webofscience.com/wos/woscc/full-record/WOS:000725239500001 https://ir.csmu.edu.tw:8080/handle/310902500/23760
Relation:	BIOLOGY-BASEL ,2021,v10,issue 11
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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