中山醫學大學機構典藏 CSMUIR:Item 310902500/23752
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    题名: Impact of pentraxin 3 genetic variants on uterine cervical cancer clinicopathologic characteristics
    作者: Sun, YH;Chou, YH;Wang, CH;Hsiao, YH;Lee, CY;Yang, SF;Wang, PH
    关键词: pentraxin 3;genetic variants;uterine cervical cancer;pelvic lymph node metastasis
    日期: 2021
    上传时间: 2022-08-05T09:42:18Z (UTC)
    出版者: IVYSPRING INT PUBL
    ISSN: 1449-1907
    摘要: The aims of this study were to investigate the relationships among pentraxin 3 (PTX3) genetic variants and development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwanese women. The study enrolled 125 patients with invasive cancer and 98 patients with precancerous lesions of uterine cervix, and 325 control women. PTX3 genetic variants rs2120243, rs3816527, rs2305619 and rs1840680 were selected and their genotypic distributions were determined by real-time polymerase chain reaction. Our results indicated that patients with genotype CC in PTX3 rs2120243 and genotype GG in rs1840680 had more chance to have adenocarcinoma but not squamous cell carcinoma, as compared to those with CA/AA and those with GA/AA, respectively. No other clinicopatholgical characteristics were associated with PTX3 genetic variants. In addition, PTX3 genetic variants were not associated with 5 years survival of cervical cancer patients. In conclusions, PTX3 genetic variants are not associated with carcinogenesis and clinicopathological variables of uterine cervix and patient survival in Taiwanese women. The only independent predictor for the 5 years survival is pelvic lymph node metastasis.
    URI: http://dx.doi.org/10.7150/ijms.57886
    https://www.webofscience.com/wos/woscc/full-record/WOS:000643794500011
    https://ir.csmu.edu.tw:8080/handle/310902500/23752
    關聯: INTERNATIONAL JOURNAL OF MEDICAL SCIENCES ,2021,v18,issue 11, P2339-2346
    显示于类别:[中山醫學大學研究成果] 期刊論文

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