Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-I3/Smad2/3 signaling inhibition

doi:10.1016/j.jfma.2021.04.012

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23750

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23750

Title:	Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-I3/Smad2/3 signaling inhibition
Authors:	Chen, PY;Ho, DCY;Liao, YW;Hsieh, PL;Lu, KH;Tsai, LL;Su, SH;Yu, CC
Keywords:	Oral submucous fibrosis;Honokiol;Buccal mucosal fibroblasts
Date:	2021
Issue Date:	2022-08-05T09:42:17Z (UTC)
Publisher:	ELSEVIER TAIWAN
ISSN:	0929-6646
Abstract:	Background/purpose: The habit of areca nut chewing has been regarded as an etiological fac-tor of precancerous oral submucous fibrosis (OSF). In the present study, we aimed to evaluate the anti-fibrosis effect of honokiol, a polyphenolic component derived from Magnolia officinalis. Methods: The cytotoxicity of honokiol was tested using normal and fibrotic buccal mucosal fi-broblasts (fBMFs) derived from OSF tissues. Collagen gel contraction, Transwell migration, in-vasion, and wound healing capacities were examined. Besides, the expression of TGF-b/Smad2 signaling as well as a-SMA and type I collagen were measured as well. Results: Honokiol exerted higher cytotoxicity of fBMFs compared to normal cells. The arecoline-induced myofibroblast activities, including collagen gel contractility, cell motility and wound healing capacities were all suppressed by honokiol treatment. In addition, the expression of the TGF-13/Smad2 pathway was downregulated along with a lower expression of a-SMA and type I collagen in honokiol-receiving cells. Conclusion: Our data suggest that honokiol may be a promising compound to alleviate the pro -gression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer. Copyright (c) 2021, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI:	http://dx.doi.org/10.1016/j.jfma.2021.04.012 https://www.webofscience.com/wos/woscc/full-record/WOS:000709764100008 https://ir.csmu.edu.tw:8080/handle/310902500/23750
Relation:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION ,2021,v120,issue 11, P1988-1993
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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