中山醫學大學機構典藏 CSMUIR:Item 310902500/23732
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    题名: Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood
    作者: Lin, CH;Chou, IC;Lee, IC;Hong, SY
    关键词: CMV infections;epilepsy;infancy;attention deficit hyperactivity disorder;autism spectrum disorder
    日期: 2021
    上传时间: 2022-08-05T09:41:58Z (UTC)
    出版者: MDPI
    摘要: Cytomegalovirus (CMV) is a ubiquitous virus, and CMV-associated diseases range from mild illness in immunologically normal hosts to life-threatening diseases in newborns and immunocompromised children. This study investigated the association between childhood CMV infection and subsequent epilepsy or neurodevelopmental disorders, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). A retrospective analysis was performed on data for 69 children with confirmed CMV infections (CMV infection group) and 292 patients with other infections (control group) between 1 January 2006 to 31 December 2012. The results indicated that the CMV infection group had a higher risk of epilepsy in comparison to the control (odds ratio (OR), 16.4; 95% CI (confidence interval), 3.32-80.7; p = 0.001). Epilepsy risk increased in younger children (age 0-2) with CMV infection when compared to the control group (OR, 32.6; 95% CI, 3.84-276; p = 0.001). The ASD risk was also determined to be higher in the CMV infection group (OR, 17.9; 95% CI, 1.96-162; p = 0.01). The ADHD risk between the groups was not significant. This study suggests that CMV infection in infancy may increase the risk of subsequent epilepsy and ASD, especially in infants younger than 2 years, but is not associated with ADHD.
    URI: http://dx.doi.org/10.3390/children8111040
    https://www.webofscience.com/wos/woscc/full-record/WOS:000727710800001
    https://ir.csmu.edu.tw:8080/handle/310902500/23732
    關聯: CHILDREN-BASEL ,2021,v8,issue 11
    显示于类别:[中山醫學大學研究成果] 期刊論文

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