Hydroxychloroquine might reduce risk of incident endometriosis in patients with systemic lupus erythematosus: A retrospective population-based cohort study

doi:10.1177/09612033211031009

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23700

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题名:	Hydroxychloroquine might reduce risk of incident endometriosis in patients with systemic lupus erythematosus: A retrospective population-based cohort study
作者:	Chen, FY;Chen, SW;Chen, XP;Huang, JY;Ye, ZZ;Wei, JCC
关键词:	Hydroxychloroquine;endometriosis;systemic lupus erythematosus;cohort study
日期:	2021
上传时间:	2022-08-05T09:41:29Z (UTC)
出版者:	SAGE PUBLICATIONS LTD
ISSN:	0961-2033
摘要:	Background SLE, which is common in women, is commonly treated with HCQ, an anti-inflammation medication. Reproductive-age women with SLE are prone to be impacted by endometriosis. This study analyzes the relationship between HCQ and endometriosis patients with SLE in order to determine whether HCQ is effective for treating the latter. Methods This population-based, retrospective cohort study analyzed the SLE risk in a cohort of newly diagnosed SLE patients with endometriosis during 2000 through 2013. Controls were selected at a 1:2 ratio through age-matching using the greedy algorithm. The Cox proportional hazard model was used to analyze the association between HCQ use and endometriosis incidence. Four different Cox regression models were used. Lastly, sensitivity analysis with PSOW and IPW was implemented to evaluate the hazard ratio (HR) of endometriosis after exposure with HCQ. Results In the cohort where age and sex matched high and low HCQ dosage, the average follow-up time was about 1 year. The cohort's overall incidence rates of endometriosis were 44.54 and 90.03 per 100000 person-month for high and low dosage respectively. The high dose group's conditional hazard ratio (aHR) for incidental endometriosis was 0.482 (CI = 0.191 to 1.213). The incidence rate and Kaplan-Meir curves of endometriosis were consistent with the results for the cohort. Conclusion This study demonstrated that SLE patients continuously treated with HCQ have a lower risk of developing endometriosis. Clinically, HCQ can be beneficial for endometriosis patients with SLE.
URI:	http://dx.doi.org/10.1177/09612033211031009 https://www.webofscience.com/wos/woscc/full-record/WOS:000676928200001 https://ir.csmu.edu.tw:8080/handle/310902500/23700
關聯:	LUPUS ,2021,v30,issue 10, P1609-1616
显示于类别:	[中山醫學大學研究成果] 期刊論文

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