Exertional Desaturation Has Higher Mortality Than Non-Desaturation in COPD

doi:10.3390/medicina57101110

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23699

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23699

Title:	Exertional Desaturation Has Higher Mortality Than Non-Desaturation in COPD
Authors:	Liu, SF;Chin, CH;Tseng, CW;Chen, YC;Kuo, HC
Keywords:	exertional desaturation;COPD;DLCO;mortality;6MWT
Date:	2021
Issue Date:	2022-08-05T09:41:28Z (UTC)
Publisher:	MDPI
ISSN:	1010-660X
Abstract:	Background and objectives: Exertional desaturation (ED) is often overlooked in chronic obstructive pulmonary disease (COPD). We aim to investigate the impact of ED on mortality and the predictors of ED in COPD. Materials and methods: A cohort of COPD patients with clinically stable, widely ranging severities were enrolled. ED is defined as oxyhemoglobin saturation by pulse oximetry (SpO2) < 90% or a drop of & UDelta;SpO2 & GE; 4% during a six-minute walk test (6MWT). Cox regression analysis is used to estimate the hazard ratio (HR) for three-year mortality. Results: A total of 113 patients were studied, including ED (N = 34) and non-ED (N = 79) groups. FVC (% of predicted value), FEV1/FVC (%), FEV1 (% of predicted value), DLCO (%), maximal inspiratory pressure, SpO2 during the 6MWT, GOLD stage, and COPD severity were significantly different between the ED and non-ED groups in univariate analysis. Low minimal SpO2 (p < 0.001) and high maximal heart rate (p = 0.04) during the 6MWT were significantly related to ED in multivariate analysis. After adjusting for age, gender, body mass index, 6MWD, FEV1, mMRC, GOLD staging, exacerbation, hs-CRP, and fibrinogen, the mortality rate of the ED group was higher than that of the non-ED group (p = 0.012; HR = 4.12; 95% CI 1.37-12.39). For deaths, the average survival time of ED was shorter than that of the non-ED group (856.4 days vs. 933.8 days, p = 0.033). Conclusions: ED has higher mortality than non-ED in COPD. COPD should be assessed for ED, especially in patients with low minimal SpO2 and high maximal HR during the 6MWT.
URI:	http://dx.doi.org/10.3390/medicina57101110 https://www.webofscience.com/wos/woscc/full-record/WOS:000726395400001 https://ir.csmu.edu.tw:8080/handle/310902500/23699
Relation:	MEDICINA-LITHUANIA ,2021,v57,issue 10
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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