Clinical features and treatment of inflammatory bowel disease in a low-incidence area A hospital-based retrospective cohort study in Taiwan

doi:10.1097/MD.0000000000025090

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23698

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题名:	Clinical features and treatment of inflammatory bowel disease in a low-incidence area A hospital-based retrospective cohort study in Taiwan
作者:	Yen, HH;Hsu, TC;Chen, MW;Su, PY;Chen, YY
关键词:	Crohn disease;inflammatory bowel disease;ulcerative colitis
日期:	2021
上传时间:	2022-08-05T09:41:27Z (UTC)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0025-7974
摘要:	Inflammatory bowel disease (IBD) has emerged in the Asia-Pacific area over the past 2 decades. There is a paucity of clinical data regarding real-world experience of patients with IBD from low endemic area such as Taiwan. Therefore, the present study aimed to review the clinical features of patients with IBD form a tertiary center from Taiwan. A total of 163 patients with IBD were identified from the electronic clinical database of Changhua Christian Hospital. Demographic data of the patients and clinical features of the disease pattern were retrospectively reviewed. There was a higher proportion (62.6%) of patients diagnosed with ulcerative colitis (UC). Patients with Crohn disease (CD) and UC had male predominance. The median age of diagnosis was younger in patients with CD than in patients with UC (CD vs UC: 31 vs 40 years, P = .0423). The disease distribution of UC was as follows: E1 (15.7%), E2 (47.1%), and E3 (37.3%). The disease distribution of CD was as follows: L1 (36.1%), L2 (14.8%), L3 (42.6%), and L4 (6.5%). The majority of patients with CD had a complicated presentation with B2 (32.8%) and B3 (32.8%). Patients with CD had a higher bowel resection rate than patients with UC. Patients with CD were more likely to be treated with immunomodulator and biologics and those with UC were more likely to be treated with 5-aminosalicylic acid (5-ASA). A trend of decreased bowel resection for patients with IBD and less severe phenotype of patients with CD were observed after 2015. UC with male predominance was the predominant type of IBD in the study. Patients with CD are likely to have a complicated disease course, requiring a higher demand of biologic therapy than patients with UC.
URI:	http://dx.doi.org/10.1097/MD.0000000000025090 https://www.webofscience.com/wos/woscc/full-record/WOS:000659034600095 https://ir.csmu.edu.tw:8080/handle/310902500/23698
關聯:	MEDICINE ,2021,v100,issue 10
显示于类别:	[中山醫學大學研究成果] 期刊論文

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