Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23691

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23691

Title:	Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species
Authors:	Fang, SY;Chen, SY;Chen, YY;Kuo, TJ;Wen, ZH;Chen, YH;Hwang, TL;Sung, PJ
Keywords:	Pseudovibrio;Aaptos;sponge;vibrindole;cytotoxicity
Date:	2021
Issue Date:	2022-08-05T09:41:20Z (UTC)
Publisher:	SAGE PUBLICATIONS INC
ISSN:	1934-578X
Abstract:	A new natural indole, vibrindole B (1), together with known analogs, vibrindole A (2), trisindoline (3), norharmane (4), and 3- (hydroxyacetyl)indole (5), produced by the bacterium Pseudovibrio denitrificans P81, were isolated from a sponge, Aaptos species. The structures of indoles 1 to 5 were established by spectroscopic methods. The proposed biosynthetic pathway of 1 to 5 is also discussed, starting from tryptophan. Moreover, indoles 1 to 3 were found to exhibit cytotoxicity toward T24 tumor cells with IC50 values of 1.71 +/- 0.11, 4.53 +/- 0.14, and 2.26 +/- 0.26 mu M, respectively.
URI:	http://dx.doi.org/10.1177/1934578X211033735 https://www.webofscience.com/wos/woscc/full-record/WOS:000702214000001 https://ir.csmu.edu.tw:8080/handle/310902500/23691
Relation:	NATURAL PRODUCT COMMUNICATIONS ,2021,v16,issue 9
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	185	View/Open