Tumor subsites and risk of osteoradionecrosis of the jaw in patients with oral cavity cancer: a national-based cohort study

doi:10.1007/s00405-020-06529-z

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23688

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23688

Title:	Tumor subsites and risk of osteoradionecrosis of the jaw in patients with oral cavity cancer: a national-based cohort study
Authors:	Liao, PH;Chu, CH;Hung, YM;Tang, PL;Kuo, TJ
Keywords:	Oral cavity cancer;Osteoradionecrosis;Cohort study;Radiotherapy
Date:	2021
Issue Date:	2022-08-05T09:41:18Z (UTC)
Publisher:	SPRINGER
ISSN:	0937-4477
Abstract:	Purpose The association between the tumor subsites of the oral cavity and the risk of osteoradionecrosis of the jaw (ORNJ) remains unclear. We study the correlation between oral cavity tumor subsites and the risk of ORNJ in a nationwide population-based database. Methods We enrolled 16,701 adult patients with oral cavity cancers who were treated with radiotherapy between 2000 and 2013. The subsites of the oral tumor, treatments of oral cavity cancers, and the timing of tooth extraction were examined for their association with ORNJ in oral cancer patients. Results 903 patients (5.40%) developed ORNJ. Of the relevant variables, pre-RT mandible surgery, tooth extraction either before or after RT, and tumor sites were associated with the risk of ORNJ. The adjusted HRs for ORNJ in the mouth floor, gums, retromolar, and buccal cancer were 2.056 (1.490-2.837), 1.909 (1.552-2.349), 1.683 (1.105-2.562), and 1.303 (1.111-1.528), respectively, compared with the risk of tongue cancer. There was no significant difference in the risk of ORNJ between the pre-RT extraction group, the during-RT extraction group, and the post-RT extraction (less than 6 months) group; the post-RT extraction (more than 6 months) group had a significantly higher risk of ORNJ. Conclusions This study demonstrated that oral cavity tumor subsite is an independent risk factor of ORNJ after RT. Post-RT extraction (less than 6 months) group did not carry a significantly higher risk of ORNJ compared with pre-RT extraction group or during RT extraction group.
URI:	http://dx.doi.org/10.1007/s00405-020-06529-z https://www.webofscience.com/wos/woscc/full-record/WOS:000604190800018 https://ir.csmu.edu.tw:8080/handle/310902500/23688
Relation:	EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY ,2021,v278,issue 9, P3425-3433
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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