中山醫學大學機構典藏 CSMUIR:Item 310902500/23679
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    题名: Macrolide Resistance, Clinical Features, and Cytokine Profiles in Taiwanese Children With Mycoplasma pneumoniae Infection
    作者: Wu, TH;Wang, NM;Liu, FC;Pan, HH;Huang, FL;Fang, YP;Chiang, TW;Yang, YY;Song, CS;Wu, HC;Lee, CY
    关键词: children;cytokine;macrolide resistance;MLVA;Mycoplasma pneumonia
    日期: 2021
    上传时间: 2022-08-05T09:41:10Z (UTC)
    出版者: OXFORD UNIV PRESS INC
    ISSN: 2328-8957
    摘要: Background. The factors that predict the progression of Mycoplasma pneumoniae infection remain inconclusive. Therefore, we investigated macrolide resistance prevalence, M pneumoniae genotype, and clinical characteristics of childhood M pneumoniae respiratory tract infections in Taiwan. Methods. A total of 295 children hospitalized with respiratory tract infections with positive serological M pneumoniae immunoglobulin M test results were enrolled in this 3-year prospective study. Oropharyngeal swabs were obtained for M pneumoniae cultures and polymerase chain reaction tests. All M pneumoniae specimens were further characterized by P1 typing, multilocus variable-number tandem-repeat analysis (MLVA), and macrolide resistance genotyping. The clinical characteristics and blood cytokine profiles were analyzed accordingly. Results. Of 138 M pneumoniae specimens, type I P1 was the predominant (136 of 138, 98.6%). The MLVA type P (4-4-5-7-2) was the leading strain (42 of 138, 30.4%), followed by type J, U, A, and X. The overall macrolide-resistant rate was 38.4% (53 of 138); the resistance rate increased dramatically yearly: 10.6% in 2017, 47.5% in 2018, and 62.5% in 2019 (P <.001). All macrolide-resistant M pneumoniae (MRMP) harbored the A2063G mutation and were MLVA type 4-5-7-2 (49 of 53, 92.5%), especially type U and X. No significant differences in clinical symptoms, duration of hospital stay, and radiographic findings were identified among patients between MRMP and macrolide-sensitive M pneumoniae (MSMP) groups. Patients with MRMP infection had more febrile days before and during hospitalization and higher interleukin (IL)-13 and IL-33 levels than patients with MSMP infection (P <.05). Conclusions. Macrolide-resistant M pneumoniae surged in Taiwan throughout the study period, but macrolide resistance was not a determinant factor of clinical severity.
    URI: http://dx.doi.org/10.1093/ofid/ofab416
    https://www.webofscience.com/wos/woscc/full-record/WOS:000715365500015
    https://ir.csmu.edu.tw:8080/handle/310902500/23679
    關聯: OPEN FORUM INFECTIOUS DISEASES ,2021,v8,issue 9
    显示于类别:[中山醫學大學研究成果] 期刊論文

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