中山醫學大學機構典藏 CSMUIR:Item 310902500/23663
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    請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23663


    題名: Liver cirrhosis affects serum lactate level measurement while assessing disease severity in patients with sepsis
    作者: Cheng, CY;Kung, CT;Wu, KH;Chen, FC;Cheng, HH;Cheng, FJ;Huang, JB;Su, CM
    關鍵詞: lactic acid;liver cirrhosis;mortality;prognosis;sepsis
    日期: 2021
    上傳時間: 2022-08-05T09:40:53Z (UTC)
    出版者: LIPPINCOTT WILLIAMS & WILKINS
    ISSN: 0954-691X
    摘要: Background Elevated serum lactate is associated with higher mortality in sepsis, whereas liver dysfunction is associated with higher serum lactate levels. We assessed the predictive ability of serum lactate in patients with liver cirrhosis and sepsis. Methods This retrospective study included 12 281 cases of suspected infection with initial serum blood lactate drawn during January 2007-December 2013. Results Using one-to-two propensity score matching analysis, 1053 and 2106 septic patients with and without underlying liver cirrhosis, respectively, were successfully matched. Lactate levels of survivors and nonsurvivors were 2.58 and 5.93 mmol/L, respectively, in patients without liver cirrhosis (WLC), 2.96 and 7.29 mmol/L, respectively, in patients with nondecompensated liver cirrhosis (NDLC), and 4.08 and 7.16 mmol/L, respectively, in patients with decompensated liver cirrhosis (DLC). In receiver operating characteristic curve analysis, the sensitivity and specificity for predicting mortality were 0.81 and 0.55, respectively, in the WLC group, 0.85 and 0.45, respectively, in the NDLC group, and 0.86 and 0.33, respectively, in the DLC group, using serum lactate levels >2.0 mmol/L. Conclusions The serum lactate level can be used to predict the severity of sepsis in patients with liver cirrhosis; however, its specificity would be lower at a cutoff of 2.0 mmol/L.
    URI: http://dx.doi.org/10.1097/MEG.0000000000001826
    https://www.webofscience.com/wos/woscc/full-record/WOS:000680632400009
    https://ir.csmu.edu.tw:8080/handle/310902500/23663
    關聯: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY ,2021,v33,issue 9, P1201-1208
    顯示於類別:[中山醫學大學研究成果] 期刊論文

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