Liver cirrhosis affects serum lactate level measurement while assessing disease severity in patients with sepsis

doi:10.1097/MEG.0000000000001826

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23663

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23663

Title:	Liver cirrhosis affects serum lactate level measurement while assessing disease severity in patients with sepsis
Authors:	Cheng, CY;Kung, CT;Wu, KH;Chen, FC;Cheng, HH;Cheng, FJ;Huang, JB;Su, CM
Keywords:	lactic acid;liver cirrhosis;mortality;prognosis;sepsis
Date:	2021
Issue Date:	2022-08-05T09:40:53Z (UTC)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0954-691X
Abstract:	Background Elevated serum lactate is associated with higher mortality in sepsis, whereas liver dysfunction is associated with higher serum lactate levels. We assessed the predictive ability of serum lactate in patients with liver cirrhosis and sepsis. Methods This retrospective study included 12 281 cases of suspected infection with initial serum blood lactate drawn during January 2007-December 2013. Results Using one-to-two propensity score matching analysis, 1053 and 2106 septic patients with and without underlying liver cirrhosis, respectively, were successfully matched. Lactate levels of survivors and nonsurvivors were 2.58 and 5.93 mmol/L, respectively, in patients without liver cirrhosis (WLC), 2.96 and 7.29 mmol/L, respectively, in patients with nondecompensated liver cirrhosis (NDLC), and 4.08 and 7.16 mmol/L, respectively, in patients with decompensated liver cirrhosis (DLC). In receiver operating characteristic curve analysis, the sensitivity and specificity for predicting mortality were 0.81 and 0.55, respectively, in the WLC group, 0.85 and 0.45, respectively, in the NDLC group, and 0.86 and 0.33, respectively, in the DLC group, using serum lactate levels >2.0 mmol/L. Conclusions The serum lactate level can be used to predict the severity of sepsis in patients with liver cirrhosis; however, its specificity would be lower at a cutoff of 2.0 mmol/L.
URI:	http://dx.doi.org/10.1097/MEG.0000000000001826 https://www.webofscience.com/wos/woscc/full-record/WOS:000680632400009 https://ir.csmu.edu.tw:8080/handle/310902500/23663
Relation:	EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY ,2021,v33,issue 9, P1201-1208
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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