中山醫學大學機構典藏 CSMUIR:Item 310902500/23660
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    题名: Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration
    作者: Lin, HH;Hsieh, MC;Wang, CP;Yu, PR;Lee, MS;Chen, JH
    关键词: gossypetin;atherosclerosis;vascular smooth muscle cells;proliferation;migration;cell-cycle;reactive oxygen species
    日期: 2021
    上传时间: 2022-08-05T09:40:50Z (UTC)
    出版者: MDPI
    摘要: Gossypetin (GTIN), known as 3,5,7,8,3 ',4 '-hexahydroxyflavone, has been demonstrated to exert anti-atherosclerotic potential against apoptotic injury in oxidized low-density lipoprotein-incubated endothelial cells, and atherosclerotic lesions of cholesterol-fed rabbits. However, the effect and underlying mechanism of GTIN on abnormal vascular smooth muscle cells (VSMCs) proliferation and migration, a major event in the pathogenesis of atherosclerosis, is still unknown. In this study, non-cytotoxic doses of GTIN abolished the VSMCs A7r5 proliferation and cell-cycle S phase distribution. The GTIN-arrested G0/G1 phase might be performed by increasing the expressions of phosphorylated p53 and its downstream molecules that inhibit the activation of cyclin E/cyclin-dependent kinase (cdk)-2, blocking retinoblastoma protein (Rb) phosphorylation and the subsequent dissociation of Rb/transcription factor E2F1 complex. In addition, the results indicated that GTIN inhibited VSMCs wound-healing and migratory abilities through reducing matrix metalloproteinase (MMP)-9 activity and expression, as well as down-regulating protein kinase B (PKB)/nuclear factor-kappaB (NF-kappa B) signaling. GTIN also revealed potential in diminishing reactive oxygen species (ROS) generation. These findings suggested the inhibitory effects of GTIN on VSMCs dysfunction could likely lead to the containment of atherosclerosis and other cardiovascular illness.
    URI: http://dx.doi.org/10.3390/antiox10091357
    https://www.webofscience.com/wos/woscc/full-record/WOS:000699278300001
    https://ir.csmu.edu.tw:8080/handle/310902500/23660
    關聯: ANTIOXIDANTS ,2021,v10,issue 9
    显示于类别:[中山醫學大學研究成果] 期刊論文

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