Incidence of dementia after dengue fever: Results of a longitudinal population-based study

doi:10.1111/ijcp.14318

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23651

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23651

Title:	Incidence of dementia after dengue fever: Results of a longitudinal population-based study
Authors:	Chang, SH;Chang, RI;Su, CS;Wei, JCC;Yip, HT;Yang, YC;Li, KY;Hung, YM
Date:	2021
Issue Date:	2022-08-05T09:40:43Z (UTC)
Publisher:	WILEY
ISSN:	1368-5031
Abstract:	Objective To investigate the epidemiological relationship between dengue fever and the subsequent development of dementia. Methods Using nationwide Taiwan registries from the National Health Insurance Research (NHIRD), we identified adults aged over 40 years who received a dengue fever diagnosis from 1 January 2000 to 31 December 2012 and who did not have a history of dementia. We used a propensity score match (PSM) to balance the baseline characteristics between groups. All eligible adults were sorted into either the dengue group or non-dengue group at a ratio of 1:4, matching by age, sex, index years, income level, and relevant comorbidities. Using Cox regression with proportional hazards models, we estimated the risk of dementia. The study period started from 1 January 2000 to 31 December 2013. We conducted sensitivity analyses to cross-validate study results. Results With a median of 8.01 years of follow-up, patients in the dengue group were more at risk of developing dementia than the non-dengue group. The estimated cumulative incidence of dementia was 7.21% in the dengue group and 4.03% in the non-dengue group (adjusted hazard ratio (aHR), 1.71; 95% CI, 1.03 to 2.83). Sensitivity analyses yielded consistent findings. We excluded any stroke cases before the end of the study, and subgroup analysis by follow-up time showed that the dengue group has a significantly higher risk of new-onset dementia >6 years after the index date (aHR 3.24; 95% CI, 1.42 to 7.37). The P value for interaction was significant (<.0001). Conclusions This study demonstrated a significantly higher risk of dementia in patients with dengue fever in Taiwan than in those without dengue fever.
URI:	http://dx.doi.org/10.1111/ijcp.14318 https://www.webofscience.com/wos/woscc/full-record/WOS:000667184200001 https://ir.csmu.edu.tw:8080/handle/310902500/23651
Relation:	INTERNATIONAL JOURNAL OF CLINICAL PRACTICE ,2021,v75,issue 8
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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