Effect of medication on risk of traumatic brain injury in patients with bipolar disorder: A nationwide population-based cohort study

doi:10.1177/02698811211013582

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23650

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23650

Title:	Effect of medication on risk of traumatic brain injury in patients with bipolar disorder: A nationwide population-based cohort study
Authors:	Liao, YT;Ku, YH;Chen, HM;Lu, ML;Chen, KJ;Yang, YH;Weng, JC;Chen, VCH
Keywords:	Bipolar disorder;traumatic brain injury;antipsychotics;psychotropics
Date:	2021
Issue Date:	2022-08-05T09:40:42Z (UTC)
Publisher:	SAGE PUBLICATIONS LTD
ISSN:	0269-8811
Abstract:	Background: Increased traumatic brain injury (TBI) risk was found in patients with bipolar disorder (BPD). Whether the medications for BPD and dosage moderate the risk of TBI is not clear. Aim: This study aimed to determine whether an association exists between BPD and TBI and whether the prescription of psychotropics moderates TBI risk. Methods: A total of 5606 individuals who had received diagnoses of BPD between January 1, 1997 and December 31, 2013 and 56,060 matched controls without BPD were identified from Taiwan's National Health Insurance Research Database. Cases and controls were followed until the date of TBI diagnosis. Results: BPD was associated with a high risk of TBI (adjusted hazard ratio (aHR): 1.85; 95% CI: 1.62-2.11). Patients with BPD, with or without a history of psychiatric hospitalization, had increased risks of TBI (aHR: 1.94, 95% CI: 1.57-2.4 and aHR: 1.82, 95% CI: 1.55-2.1, respectively). The prescription of typical antipsychotics (0 < defined daily dose (DDD) < 28: hazard ratio (HR) = 1.52, 95% CI: 1.19-1.94; > 28 DDD: HR = 1.54, 95% CI: 1.15-2.06) and tricyclic antidepressants (TCAs) (0 < DDD < 28: HR = 1.73, 95% CI: 1.26-2.39; > 28 DDD: HR = 1.52, 95% CI: 1.02-2.25) was associated with higher TBI risk. Patients receiving higher doses of benzodiazepines (BZDs) (cumulative dose > 28 DDD) had a higher TBI risk (HR = 1.53, 95% CI: 1.13-2.06). Conclusion: Patients with BPD have a higher risk of TBI. The use of typical antipsychotics, TCAs, or high-dose BZDs increases the risk of TBI in BPD.
URI:	http://dx.doi.org/10.1177/02698811211013582 https://www.webofscience.com/wos/woscc/full-record/WOS:000651186900001 https://ir.csmu.edu.tw:8080/handle/310902500/23650
Relation:	JOURNAL OF PSYCHOPHARMACOLOGY ,2021,v35,issue 8, P962-970
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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