中山醫學大學機構典藏 CSMUIR:Item 310902500/23638
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    题名: Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?-A Retrospective Study
    作者: Lin, CH;Lin, WD;Chou, IC;Lee, IC;Hong, SY
    关键词: epilepsy;preterm;attention deficit hyperactivity disorder;autism spectrum disorder;neurodevelopmental disorders
    日期: 2021
    上传时间: 2022-08-05T09:40:31Z (UTC)
    出版者: MDPI
    摘要: Febrile seizure (FS) is the most prevalent childhood seizure; it is significantly related to subsequent epilepsy and has possible links to childhood neurodevelopmental disorders. Separately, premature births are believed to increase the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Therefore, this study investigated whether preterm birth is a risk factor for subsequent epilepsy, ASD, and ADHD in children with FS. We retrospectively collected data for children aged < 5 years with FS from 1 January 2005, to 31 December 2013. We divided these children into two groups-the premature birth group and the full-term group-and compared their incidence rates of epilepsy, ASD and ADHD. The data of 426 patients with history of febrile convulsion were retrospectively collected. The premature birth group (FS+/preterm+) had 108 patients and the full-term group (FS+/preterm-) had 318 patients. The overall epilepsy risk in the FS+/preterm+ group was higher than in the FS+/preterm- group (odds ratio [OR], 2.52; 95% confidence interval [CI], 1.14-5.58; p = 0.02). The overall risk of ADHD in the FS+/preterm+ group was higher than that in the FS+/preterm- group (OR, 6.41; 95% CI, 3.39-12.09; p = 0.0001). In addition, children with FS+/preterm+ had 16.9 times (95% CI, 4.79-59.7; p = 0.0001) higher odds of having ASD compared with those with FS+/preterm-. Preterm birth may be a risk factor for subsequent epilepsy, ASD and ADHD in children with FS.
    URI: http://dx.doi.org/10.3390/life11080854
    https://www.webofscience.com/wos/woscc/full-record/WOS:000689587900001
    https://ir.csmu.edu.tw:8080/handle/310902500/23638
    關聯: LIFE-BASEL ,2021,v11,issue 8
    显示于类别:[中山醫學大學研究成果] 期刊論文

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