Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study

doi:10.18632/aging.202820

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23611

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23611

Title:	Differential relationship of uric acid to mortality and clinical biomarkers of aging according to grip strength in older adults: a cohort study
Authors:	Guo, SM;Liu, YT;He, SR;Wu, MS;Tseng, WT;Wu, RC;Wu, IC
Keywords:	biomarkers;oxidative stress;epidemiology;physiology;aging
Date:	2021
Issue Date:	2022-08-05T09:40:05Z (UTC)
Publisher:	IMPACT JOURNALS LLC
ISSN:	1945-4589
Abstract:	Uric acid is both a pro-oxidant and antioxidant. We investigated serum uric acid's association with mortality and aging biomarkers in older adults with varying levels of grip strength. A total of 5329 community-dwelling adults aged >= 55 years underwent assessments of serum uric acid levels, grip strength, and biomarkers of diverse physiological systems. The primary outcome was all-cause mortality. We observed a significant (P < .001) interaction between uric acid levels and grip strength on all-cause mortality risk. Among participants with low grip strength, a nonlinear association (P for nonlinearity = .006) was observed between serum uric acid levels and mortality risk after multivariate adjustment. Compared with participants with neither extreme uric acid levels nor low grip strength, those with a combination of high serum uric acid and low grip strength exhibited greater risks of mortality (adjusted hazard ratio [aHR], 1.52; 95% confidence interval [CI], 1.15-2.02) and deviations in biomarkers of specific systems, so did those with a combination of low serum uric acid and low grip strength (aHR, 1.52; 95% CI, 1.13-2.05). In conclusion, there was a J-shaped association between serum uric acid and the risk of all-cause mortality in older adults. This was primarily true for those with low grip strength.
URI:	http://dx.doi.org/10.18632/aging.202820 https://www.webofscience.com/wos/woscc/full-record/WOS:000657258800007 https://ir.csmu.edu.tw:8080/handle/310902500/23611
Relation:	AGING-US ,2021,v13,issue 7, P10555-10583
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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