Increased risk of rheumatoid arthritis among patients with endometriosis: a nationwide population-based cohort study

doi:10.1093/rheumatology/keaa784

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23606

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23606

Title:	Increased risk of rheumatoid arthritis among patients with endometriosis: a nationwide population-based cohort study
Authors:	Xue, YH;You, LT;Ting, HF;Chen, YW;Sheng, ZY;Xie, YD;Wang, YH;Chiou, JY;Wei, JCC
Keywords:	rheumatoid arthritis;endometriosis;autoimmune disease;NSAID
Date:	2021
Issue Date:	2022-08-05T09:40:01Z (UTC)
Publisher:	OXFORD UNIV PRESS
ISSN:	1462-0324
Abstract:	Objectives: Autoimmunity may play a role in endometriosis. The association between endometriosis and RA remains unknown. This study was conducted to identify any evidence for this relationship. Methods: This 13-year, nationwide, population-based, retrospective cohort study analysed the risk of RA in a cohort of individuals with endometriosis. We investigated the incidence of RA among patients with endometriosis using data from the Longitudinal Health Insurance Database 2000, which is maintained by the Taiwan National Health Research Institutes. We used propensity scores to match comorbidities in the two cohorts. Kaplan-Meier analysis and Cox proportional hazard model were employed to analyse the association between endometriosis and RA among patients with different potential risks. Results: Patients with endometriosis [adjusted hazard ratio (HR) 1.75, 95% CI 1.27, 2.41], aged >= 45 years (adjusted HR 1.50, 95% CI 1.06-2.13) and with autoimmune disease (adjusted HR 6.99, 95% CI 2.84-17.21) had a significantly higher risk of RA. The analyses also showed that when stratified by age, comorbidities and medication use, the risk of RA in patients with endometriosis was also higher than in those without endometriosis. Conclusions: This 14-year, nationwide, population-based retrospective cohort study revealed that patients with endometriosis have a higher risk of RA. In the clinical management of patients with RA, rheumatologists should be especially mindful of the possibility of underlying endometriosis.
URI:	http://dx.doi.org/10.1093/rheumatology/keaa784 https://www.webofscience.com/wos/woscc/full-record/WOS:000672804500052 https://ir.csmu.edu.tw:8080/handle/310902500/23606
Relation:	RHEUMATOLOGY ,2021,v60,issue 7, P3326-3333
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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