The Enhancing Effect of Fungal Immunomodulatory Protein-Volvariella Volvacea (FIP-vvo) on Maturation and Function of Mouse Dendritic Cells

doi:10.3390/life11060471

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23591

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23591

Title:	The Enhancing Effect of Fungal Immunomodulatory Protein-Volvariella Volvacea (FIP-vvo) on Maturation and Function of Mouse Dendritic Cells
Authors:	Li, JP;Lee, YP;Ma, JC;Liu, BR;Hsieh, NT;Chen, DC;Chu, CL;You, RI
Keywords:	fungal immunomodulatory proteins (FIPs);FIP-vvo;dendritic cell (DC)
Date:	2021
Issue Date:	2022-08-05T09:39:45Z (UTC)
Publisher:	MDPI
Abstract:	Volvariella volvacea, also known as straw mushroom, is a common edible mushroom in Chinese cuisine. It contains many nutrients for human health. A fungal immunomodulatory protein (FIP) has been isolated from V. volvacea and named FIP-vvo. Although the regulatory effects of many FIPs on immunity have been identified, the impact of FIP-vvo in modulating dendritic cells (DCs), which play a key role to connect the innate and the adaptive immunity, is not known. In this study, we aim to study the effect of FIP-vvo on the DC maturation and function. We found that FIP-vvo slightly increased the generation of CD11c(+) bone marrow-derived DC (BMDC). In addition, the surface expression of MHCII was promoted in BMDCs after the treatment of FIP-vvo, suggesting that FIP-vvo induces DC maturation. Furthermore, FIP-vvo enhanced the ability of BMDCs to activate antigen-specific T cell responses in vitro. In the in vivo study, the FIP-vvo treatment facilitated T cell response in lymph nodes. Therefore, for the first time, our data demonstrated that FIP-vvo promoted DC maturation and function and suggested that FIP-vvo could have benefits for human health by enhancing immunity.
URI:	http://dx.doi.org/10.3390/life11060471 https://www.webofscience.com/wos/woscc/full-record/WOS:000666016400001 https://ir.csmu.edu.tw:8080/handle/310902500/23591
Relation:	LIFE-BASEL ,2021,v11,issue 6
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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