Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study

doi:10.3390/toxics9060117

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23577

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23577

Title:	Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study
Authors:	Lin, WD;Ou, CC;Hsiao, SH;Chang, CH;Tsai, FJ;Liao, JW;Chen, YT
Keywords:	acrylamide;vasorelaxation;neurotoxicity;nitric oxide synthase;nicotinic acetylcholine receptor
Date:	2021
Issue Date:	2022-08-05T09:39:32Z (UTC)
Publisher:	MDPI
Abstract:	Acrylamide (ACR), which is formed during the Maillard reaction, is used in various industrial processes. ACR accumulation in humans and laboratory animals results in genotoxicity, carcinogenicity, neurotoxicity, and reproductive toxicity. In this study, we investigated the mechanisms by which ACR may induce vasorelaxation and neuromuscular toxicity. Vasorelaxation was studied using an isolated rat aortic ring model. The aortic rings were divided into the following groups: with or without endothelium, with nitric oxide synthase (NOS) inhibition, with acetylcholine receptor inhibition, and with extracellular calcium inhibition. Changes in tension were used to indicate vasorelaxation. Neuromuscular toxicity was assessed using a phrenic nerve-diaphragm model. Changes in muscle contraction stimulated by the phrenic nerve were used to indicate neuromuscular toxicity. ACR induced the vasorelaxation of phenylephrine-precontracted aortic rings, which could be significantly attenuated by NOS inhibitors. The results of the phrenic nerve-diaphragm experiments revealed that ACR reduced muscle stimulation and contraction through nicotinic acetylcholine receptor (AChR). ACR-induced vasotoxicity was regulated by NOS through the aortic endothelium. Nicotinic AChR regulated ACR-induced neuromuscular blockage.
URI:	http://dx.doi.org/10.3390/toxics9060117 https://www.webofscience.com/wos/woscc/full-record/WOS:000666693300001 https://ir.csmu.edu.tw:8080/handle/310902500/23577
Relation:	TOXICS ,2021,v9,issue 6
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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