中山醫學大學機構典藏 CSMUIR:Item 310902500/23546
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    题名: Host Genetic Associations with Salivary Microbiome in Oral Cancer
    作者: Yang, SF;Lin, CW;Chuang, CY;Lee, YC;Chung, WH;Lai, HC;Chang, LC;Su, SC
    关键词: oral squamous cell carcinoma;oral microbiota;dysbiosis;genotype;quantitative trait loci;microbiome genome-wide association study
    日期: 2021
    上传时间: 2022-08-05T09:39:01Z (UTC)
    出版者: SAGE PUBLICATIONS INC
    ISSN: 0022-0345
    摘要: Despite the growing recognition of a host genetic effect on shaping gut microbiota composition, the genetic determinants of oral microbiota remain largely unexplored, especially in the context of oral diseases. Here, we performed a microbiome genome-wide association study in 2 independent cohorts of patients with oral squamous cell carcinoma (OSCC, n = 144 and 67) and an additional group of noncancer individuals (n = 104). Besides oral bacterial dysbiosis and signatures observed in OSCC, associations of 3 loci with the abundance of genus-level taxa and 4 loci with beta diversity measures were detected (q < 0.05) at the discovery stage. The most significant hit (rs10906082 with the genus Lachnoanaerobaculum, P = 3.55 x 10(-9) at discovery stage) was replicated in a second OSCC cohort. Moreover, the other 2 taxonomical associations, rs10973953 with the genus Kingella (P = 1.38 x 10(-9)) and rs4721629 with the genus Parvimonas (P = 3.53 x 10(-8)), were suggestive in the meta-analysis combining 2 OSCC cohorts. Further pathway analysis revealed that these loci were enriched for genes in regulation of oncogenic and angiogenic responses, implicating a genetic anchor to the oral microbiome in estimation of casual relationships with OSCC. Our findings delineate the role of host genotypes in influencing the structure of oral microbial communities.
    URI: http://dx.doi.org/10.1177/00220345211051967
    https://www.webofscience.com/wos/woscc/full-record/WOS:000729499100001
    https://ir.csmu.edu.tw:8080/handle/310902500/23546
    關聯: JOURNAL OF DENTAL RESEARCH ,2022,v101,issue 5, P590-598
    显示于类别:[中山醫學大學研究成果] 期刊論文

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