中山醫學大學機構典藏 CSMUIR:Item 310902500/23530
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    题名: Carbonic Anhydrase IX Promotes Human Cervical Cancer Cell Motility by Regulating PFKFB4 Expression
    作者: Hsin, MC;Hsieh, YH;Hsiao, YH;Chen, PN;Wang, PH;Yang, SF
    关键词: CAIX;PFKFB4;cervical cancer;metastasis
    日期: 2021
    上传时间: 2022-08-05T09:38:45Z (UTC)
    出版者: MDPI
    摘要: Simple Summary Carbonic anhydrase IX (CAIX) is a hypoxia-induced protein that is highly expressed in numerous human cancers. However, the molecular mechanisms involved in CAIX and human cervical cancer metastasis remain poorly understood. Our study found that CAIX overexpression increases PFKFB4 expression and EMT, promoting cervical cancer cell migration. CAIX could contribute to cervical cancer cell metastasis and its inhibition could be a cervical cancer treatment strategy. Carbonic anhydrase IX (CAIX) is a hypoxia-induced protein that is highly expressed in numerous human cancers. However, the molecular mechanisms involved in CAIX and human cervical cancer metastasis remain poorly understood. In this study, CAIX overexpression in SiHa cells increased cell migration and epithelial-to-mesenchymal transition (EMT). Silencing CAIX in the Caski cell line decreased the motility of cells and EMT. Furthermore, the RNA-sequencing analysis identified a target gene, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB4), which is influenced by CAIX overexpression and knockdown. A positive correlation was found between CAIX expression and PFKFB4 levels in the cervical cancer of the TCGA database. Mechanistically, CAIX overexpression activated the phosphorylation of extracellular signal-regulated kinases (ERKs) to induce EMT and promote cell migration. In clinical results, human cervical cancer patients with CAIX(high)/PFKFB4(high) expression in the late stage had higher rates of lymph node metastasis and the shortest survival time. Our study found that CAIX overexpression increases PFKFB4 expression and EMT, promoting cervical cancer cell migration. CAIX could contribute to cervical cancer cell metastasis and its inhibition could be a cervical cancer treatment strategy.
    URI: http://dx.doi.org/10.3390/cancers13051174
    https://www.webofscience.com/wos/woscc/full-record/WOS:000627945500001
    https://ir.csmu.edu.tw:8080/handle/310902500/23530
    關聯: CANCERS ,2021,v13,issue 5
    显示于类别:[中山醫學大學研究成果] 期刊論文

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