Glycerol Improves Intracerebral Hemorrhagic Brain Injury and Associated Kidney Dysfunction in Rats

doi:10.3390/antiox10040623

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23502

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23502

Title:	Glycerol Improves Intracerebral Hemorrhagic Brain Injury and Associated Kidney Dysfunction in Rats
Authors:	Chang, CY;Pan, PH;Li, JR;Ou, YC;Liao, SL;Chen, WY;Kuan, YH;Chen, CJ
Keywords:	brain edema;hemorrhagic stroke;intracranial pressure;kidney dysfunction;stress hormones
Date:	2021
Issue Date:	2022-08-05T09:38:19Z (UTC)
Publisher:	MDPI
Abstract:	In stroke patients, the development of acute kidney injury (AKI) is closely linked with worse outcomes and increased mortality. In this study, the interplay between post-stroke and AKI and treatment options was investigated in a rodent model of hemorrhagic stroke. Intrastriatal collagenase injection for 24 h caused neurological deficits, hematoma formation, brain edema, apoptosis, blood-brain barrier disruption, oxidative stress, and neuroinflammation in Sprague Dawley rats. Elevation of serum blood urea nitrogen, serum creatinine, urine cytokine-induced neutrophil chemoattractant-1, and urine Malondialdehyde, as well as moderate histological abnormality in the kidney near the glomerulus, indicated evidence of kidney dysfunction. The accumulation of podocalyxin DNA in urine further suggested a detachment of podocytes and structural deterioration of the glomerulus. Circulating levels of stress hormones, such as epinephrine, norepinephrine, corticosterone, and angiotensin II were elevated in rats with intracerebral hemorrhage. Osmotic agent glycerol held promising effects in alleviating post-stroke brain injury and kidney dysfunction. Although the detailed protective mechanisms of glycerol have yet to be determined, the intrastriatal collagenase injection hemorrhagic stroke model in rats allowed us to demonstrate the functional and structural integrity of glomerulus are targets that are vulnerable to post-stroke injury and stress hormones could be surrogates of remote communications.
URI:	http://dx.doi.org/10.3390/antiox10040623 https://www.webofscience.com/wos/woscc/full-record/WOS:000642733700001 https://ir.csmu.edu.tw:8080/handle/310902500/23502
Relation:	ANTIOXIDANTS ,2021,v10,issue 4
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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