中山醫學大學機構典藏 CSMUIR:Item 310902500/23501
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    题名: Ocimum Gratissimum Extract Induces Apoptosis in Gastric Cancer Cells via Modulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase
    作者: Sheu, MJ;Tsai, JN;Tam, WL;Liu, JY;Hsu, LS
    关键词: Apoptosis;Gastric cancer;Mitogen-activated protein kinase;Ocimum gratissimum extract;Reactive oxygen species
    日期: 2021
    上传时间: 2022-08-05T09:38:19Z (UTC)
    出版者: NEW CENTURY HEALTH PUBLISHERS, LLC
    ISSN: 1540-7535
    摘要: Given the increasing incidence of gastric cancer and its high rate of metastasis, drug resistance and the mortality rate remain high. Ocimum gratissimum, a botanical species of Ocimum known to exhibit general anti-inflammatory, antioxidant, and anticancer activities has not yet been evaluated for gastric cancer proliferation. In this study, we have demonstrated that O. gratissimum extract significantly reduces the viability of gastric cancer cells by triggering apoptosis, elevating levels of ROS, and enhanced cleavage of poly-ADP-ribose polymerase and caspase-3. Western blot analysis indicated that O. gratissimum extract enhanced the cleavage of PARP and caspase-3. Moreover, O. gratissimum extract inhibited extracellular signal-regulated kinase 1/2 and increased activities of p38, a stress stimulated kinase. In conclusion, our findings show that O. gratissimum extract may be a potential antigastric cancer agent.
    URI: http://dx.doi.org/10.37290/ctnr2641-452X.19:514-519
    https://www.webofscience.com/wos/woscc/full-record/WOS:000674702700021
    https://ir.csmu.edu.tw:8080/handle/310902500/23501
    關聯: CURRENT TOPICS IN NUTRACEUTICAL RESEARCH ,2021,v19,issue 4, P514-519
    显示于类别:[中山醫學大學研究成果] 期刊論文

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