Therapeutic Effect of Cinnamomum osmophloeum Leaf Extract on Oral Mucositis Model Rats Induced by 5-Fluororacil via Influencing IL-1 beta and IL-6 Levels

doi:10.3390/pr9040615

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23494

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23494

Title:	Therapeutic Effect of Cinnamomum osmophloeum Leaf Extract on Oral Mucositis Model Rats Induced by 5-Fluororacil via Influencing IL-1 beta and IL-6 Levels
Authors:	Bakar, A;Ningrum, V;Lee, SC;Li, CT;Hsieh, CW;Wang, SH;Tsai, MS
Keywords:	Cinnamomum osmophloeum;Oral mucositis;model rat;5-Fluororacil;IL-1 beta;IL-6
Date:	2021
Issue Date:	2022-08-05T09:38:11Z (UTC)
Publisher:	MDPI
Abstract:	Oral mucositis (OM) is the oral inflammation as manifestation of chemotherapy and/or radiotherapy. Cinnamomum osmophloeum (CO), of which the constituents possess anti-inflammatory activities, may have potential to alleviate OM. In this study, laboratory rats were injected with 5-Fluororacil and their oral mucosa were irritated by 18-gauge needle pouching to induce OM. Rats were randomly divided into six experimental groups: without treatment (WT), only 100 mg/mL CO leaf extract (COLE) treatment (100-only), only 5-Fluororacil treatment (5-FU), 5-FU then treated with Triamcinolone acetonide orobase (5-FU+G), 5-FU then treated with 50 mg/mL COLE, and 5-FU then treated with 100 mg/mL COLE (5-FU+100). Body weights and food and water intakes during the experimental period were recorded. Macroscopic examination, histopathological analyses, and serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) levels of these rats were evaluated or determined. No significant difference was found between the WT and 100-only groups. Results of macroscopic examinations, histopathological analyses, body weight changes, food and water intakes, and serum IL-1 beta and IL-6 levels showed significant therapeutic effects of the 5-FU+100 group compared to the 5-FU group. These finding suggest that COLE can be one of potential remedies for OM therapy through influencing proinflammatory cytokine levels.
URI:	http://dx.doi.org/10.3390/pr9040615 https://www.webofscience.com/wos/woscc/full-record/WOS:000643615100001 https://ir.csmu.edu.tw:8080/handle/310902500/23494
Relation:	PROCESSES ,2021,v9,issue 4
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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