Risk of Breast Cancer in Females With Hypothyroidism: A Nationwide, Population-Based, Cohort Study

doi:10.1016/j.eprac.2020.09.007

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23492

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23492

Title:	Risk of Breast Cancer in Females With Hypothyroidism: A Nationwide, Population-Based, Cohort Study
Authors:	Huang, CH;Wei, JCC;Chien, TC;Kuo, CW;Lin, SH;Su, YC;Hsu, CY;Chiou, JY;Yeh, MH
Keywords:	breast cancer;cohort study;hypothyroidism;levothyroxine;Longitudinal Health Insurance Database;National Health Insurance Research;Database
Date:	2021
Issue Date:	2022-08-05T09:38:09Z (UTC)
Publisher:	ELSEVIER INC
ISSN:	1530-891X
Abstract:	Objectives: The results of studies investigating the relationship between breast cancer and hypothyroidism vary greatly from study to study. In this study, we analyzed a large and reliable, population-based database to gain a better understanding of the correlation. Methods: This retrospective cohort study analyzed patients with hypothyroidism between January 1, 2000 and December 31, 2012 (hypothyroidism cohort) from the Longitudinal Health Insurance Database 2000 in Taiwan. For each woman with hypothyroidism, 1 woman without a history of breast cancer was randomly selected from the Longitudinal Health Insurance Database 2000 and frequency matched (1:4) with women without hypothyroidism by age and index year of hypothyroidism. The study outcome was the diagnosis of breast cancer during a 12-year follow-up period. Results: In this study, 6665 women with hypothyroidism and 26 660 women without hypothyroidism were identified. The hypothyroidism cohort had a significantly higher risk of breast cancer than the nonhypothyroidism cohort (adjusted hazard ratio [aHR] 1.69 [95% CI, 1.15-2.49]; P = .01), especially in the group aged 40 to 64 years (aHR 2.07 [95% CI, 1.32-3.23]; P = .01). Women in the hypothyroidism cohort taking levothyroxine for a duration .588 days showed a significantly decreased risk of breast cancer (aHR 0.37 [95% CI, 0.19-0.71]; P = .003). Conclusion: Women with hypothyroidism are at a higher risk of breast cancer than those without hypothyroidism. Levothyroxine may reduce the risk of breast cancer in a woman with hypothyroidism. (C) 2020 AACE. Published by Elsevier Inc. All rights reserved.
URI:	http://dx.doi.org/10.1016/j.eprac.2020.09.007 https://www.webofscience.com/wos/woscc/full-record/WOS:000637317300005 https://ir.csmu.edu.tw:8080/handle/310902500/23492
Relation:	ENDOCRINE PRACTICE ,2021,v27,issue 4, P298-305
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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