PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study

doi:10.21873/anticanres.14991

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23484

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題名:	PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study
作者:	Yu, WN;Lin, HF;Lee, Y;Shia, WC;Sung, WW;Yeh, CM;Lin, YM
關鍵詞:	PBK;PDZ binding kinase;prognosis;oral cancer;radiotherapy
日期:	2021
上傳時間:	2022-08-05T09:38:02Z (UTC)
出版者:	INT INST ANTICANCER RESEARCH
ISSN:	0250-7005
摘要:	Background/Aim: To investigate the impact PDZ-binding kinase (PBK) on the clinical outcome of patients with oral squamous cell carcinoma (OSCC) who received radiotherapy. Patients and Methods: PBK immunoreactivity of cancer specimens obtained from 179 patients with primary OSCC was analyzed by immunohistochemistry. Results: High PBK expression in tumor cells tended to be associated with advanced N-stage. The 5-year survival rate was greater for patients with high total PBK expression than in those with low PBK expression. After adjustment, high PBK remained associated with a favorable outcome. In subgroups according to tumor stage, the prognostic role was significant in patients with stage III/IV rather than those with stage I/II disease. Conclusion: We suggest that PBK expression should be used as an independent prognostic marker for patients with OSCC treated with radiotherapy, especially for those with advanced-stage disease.
URI:	http://dx.doi.org/10.21873/anticanres.14991 https://www.webofscience.com/wos/woscc/full-record/WOS:000637198100022 https://ir.csmu.edu.tw:8080/handle/310902500/23484
關聯:	ANTICANCER RESEARCH ,2021,v41,issue 4, P2177-2182
顯示於類別:	[中山醫學大學研究成果] 期刊論文

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