Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo-controlled, double-blind, cross-over clinical trial

doi:10.1111/jfbc.13665

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23476

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23476

Title:	Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo-controlled, double-blind, cross-over clinical trial
Authors:	Chiu, HF;Lee, HJ;Han, YC;Venkatakrishnan, K;Golovinskaia, O;Wang, CK
Keywords:	anti‐ inflammatory;antioxidant;Chlorella pyrenoidosa;oxidative stress
Date:	2021
Issue Date:	2022-08-05T09:37:55Z (UTC)
Publisher:	WILEY
ISSN:	0145-8884
Abstract:	The current study aims to explore the anti-inflammatory activity of Chlorella pyrenoidosa on RAW 267.4 cells and followed by a cross-over clinical trial in healthy subjects to check the antioxidant and anti-aging properties of Chlorella water extract (CWE). For the clinical trial, 44 healthy subjects were requested to consume 27 ml of either placebo or CWE for 90 days (phase I) and vice-versa manner for 90 days (phase II) with 4 weeks of washout period. The RAW 264.7 macrophages treated with Chlorella display potent anti-inflammatory activity by significantly downregulating (p < .05) the protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Whereas, the subjects supplemented with CWE showed improved (p < .05) antioxidant status (TEAC, SOD, CAT, and DHEAs) and lower (p < .05) oxidative stress/aging markers (TBARS and 8-OHdG) as well as considerably (p < .05) protected liver (by lowering GOT and GPT). Thus, consumption of chlorella could significantly improve the overall health status by suppressing various oxidative stress markers and aging stress markers. Practical applications Chlorella is considered as a popular functional food owing to its rich nutrient value and its array of biological activities. Numerous studies indicated that treatment with Chlorella spp. would considerably lower oxidative stress, inflammation, and regulate immune response which might contribute to anti-aging property in various cell and animal models. Based on the above information, we expected that Chlorella would be a better contender for the development of a novel anti-aging agent. Hence, we designed this clinical trial to assess the beneficial effects of Chlorella pyrenoidosa especially anti-aging. In agreement with our hypothesis, our results also showed that subjected supplemented with Chlorella water extract could significantly improve overall health status by suppressing various oxidative stress markers and aging stress markers. Hence, Chlorella could be developed into a novel anti-aging agent. In the future, it can be prescribed with standard anti-aging agents to improve the overall health status of the elderly population. However, large-scale clinical studies are needed to confirm our statements.
URI:	http://dx.doi.org/10.1111/jfbc.13665 https://www.webofscience.com/wos/woscc/full-record/WOS:000631500700001 https://ir.csmu.edu.tw:8080/handle/310902500/23476
Relation:	JOURNAL OF FOOD BIOCHEMISTRY ,2021,v45,issue 4
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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