中山醫學大學機構典藏 CSMUIR:Item 310902500/23469
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    题名: Synergistic Photoantimicrobial Chemotherapy of Methylene Blue-Encapsulated Chitosan on Biofilm-Contaminated Titanium
    作者: Lin, CN;Ding, SJ;Chen, CC
    关键词: dental implant;peri-implantitis;photoantimicrobial chemotherapy;methylene blue;chitosan
    日期: 2021
    上传时间: 2022-08-05T09:37:49Z (UTC)
    出版者: MDPI
    摘要: Intensive efforts have been made to eliminate or substantial reduce bacterial adhesion and biofilm formation on titanium implants. However, in the management of peri-implantitis, the methylene blue (MB) photosensitizer commonly used in photoantimicrobial chemotherapy (PACT) is limited to a low retention on the implant surface. The purpose of this study was to assess enhancive effect of water-soluble quaternary ammonium chitosan (QTS) on MB retention on biofilm-infected SLA (sandblasted, large grid, and acid-etched) Ti alloy surfaces in vitro. The effectiveness of QTS + MB with different concentrations in eliminating Gram-negative A. actinomycetemcomitans or Gram-positive S. mutans bacteria was compared before and after PACT. Bacterial counting and lipopolysaccharide (LPS) detection were examined, and then the growth of human osteoblast-like MG63 cells was evaluated. The results indicated that the synergistic QTS + MB with retention ability significantly decreased the biofilm accumulation on the Ti alloy surface, which was better than the same concentration of 1 wt% methyl cellulose (MC). More importantly, the osteogenic activity of MG63 cells on the disinfected sample treated by QTS + MB-PACT modality was comparable to that of sterile Ti control, significantly higher than that by MC + MB-PACT modality. It is concluded that, in terms of improved retention efficacy, effective bacteria eradication, and enhanced cell growth, synergistically, PACT using the 100 mu g/mL MB-encapsulated 1% QTS was a promising modality for the treatment of peri-implantitis.
    URI: http://dx.doi.org/10.3390/ph14040346
    https://www.webofscience.com/wos/woscc/full-record/WOS:000643401300001
    https://ir.csmu.edu.tw:8080/handle/310902500/23469
    關聯: PHARMACEUTICALS ,2021,v14,issue 4
    显示于类别:[中山醫學大學研究成果] 期刊論文

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